Recombinant Human Siglec-2/CD22 Protein

Product Description

Recombinant Human Siglec-2/CD22 Protein
Catalog number: B2019218
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: 76.6 kDa
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: SIGLEC-2 Protein, Human; SIGLEC2 Protein, Human
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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2: Dhillon S. Moxetumomab Pasudotox: First Global Approval Drugs. 2018 Nov;78(16):1763-1767.
3: Wayne AS, Fitzgerald DJ, Kreitman RJ, Pastan I. Immunotoxins for leukemia Blood. 2014 Apr 17;123(16):2470-7.
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5: Madge PD, Maggioni A, Pascolutti M, Amin M, Waespy M, Bellette B, Thomson RJ, Kelm S, von Itzstein M, Haselhorst T. Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt’s lymphoma (BL) Daudi cells by NMR spectroscopy Sci Rep. 2016 Nov 3;6:36012.
6: Kreitman RJ, Pastan I. Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox Clin Cancer Res. 2011 Oct 15;17(20):6398-405.
7: Hanasaki K, Varki A, Powell LD. CD22-mediated cell adhesion to cytokine-activated human endothelial cells. Positive and negative regulation by alpha 2-6-sialylation of cellular glycoproteins J Biol Chem. 1995 Mar 31;270(13):7533-42.
8: Kreitman RJ. Immunotoxins for targeted cancer therapy AAPS J. 2006 Aug 18;8(3):E532-51.
9: Fancher KM, Lally-Montgomery ZC. Moxetumomab pasudotox: A first-in-class treatment for hairy cell leukemia J Oncol Pharm Pract. 2019 Sep;25(6):1467-1472.
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