Recombinant Human PCSK9 Protein (Highy Pure)

Description

Recombinant Human PCSK9 Protein
Catalog number: B2012787
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 ug
Molecular Weight or Concentration: 71.3 kDa
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Kininogen 1 Protein, Human, Recombinant (His Tag)
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Xiao Q, Li X, Li Y, Wu Z, Xu C, Chen Z, He W. Biological drug and drug delivery-mediated immunotherapy Acta Pharm Sin B. 2021 Apr;11(4):941-960.
2: Vincent JL, Francois B, Zabolotskikh I, Daga MK, Lascarrou JB, Kirov MY, Pettilä V, Wittebole X, Meziani F, Mercier E, Lobo SM, Barie PS, Crowther M, Esmon CT, Fareed J, Gando S, Gorelick KJ, Levi M, Mira JP, Opal SM, Parrillo J, Russell JA, Saito H, Tsuruta K, Sakai T, Fineberg D; SCARLET Trial Group. Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial JAMA. 2019 May 28;321(20):1993-2002.
3: Lupo MG, Bressan A, Donato M, Canzano P, Camera M, Poggio P, Greco MF, Garofalo M, De Martin S, Panighel G, Ruscica M, Baragetti A, Bollati V, Faggin E, Rattazzi M, Catapano AL, Ferri N. PCSK9 promotes arterial medial calcification Atherosclerosis. 2022 Apr;346:86-97.
4: Annex BH, Cooke JP. New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease Circ Res. 2021 Jun 11;128(12):1944-1957.
5: Guo Y, Tang Z, Yan B, Yin H, Tai S, Peng J, Cui Y, Gui Y, Belke D, Zhou S, Zheng XL. PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Triggers Vascular Smooth Muscle Cell Senescence and Apoptosis: Implication of Its Direct Role in Degenerative Vascular Disease Arterioscler Thromb Vasc Biol. 2022 Jan;42(1):67-86.
6: Wang M, Zhao D, Xu L, Guo W, Nie L, Lei Y, Long Y, Liu M, Wang Y, Zhang X, Zhang L, Li H, Zhang J, Yuan D, Yue L. Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome Metabolism. 2019 May;94:47-58.
7: Demers A, Samami S, Lauzier B, Des Rosiers C, Ngo Sock ET, Ong H, Mayer G. PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse Liver Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2517-25.
8: Scalise V, Sanguinetti C, Neri T, Cianchetti S, Lai M, Carnicelli V, Celi A, Pedrinelli R. PCSK9 Induces Tissue Factor Expression by Activation of TLR4/NFkB Signaling Int J Mol Sci. 2021 Nov 23;22(23):12640.
9: Ding Z, Wang X, Liu S, Shahanawaz J, Theus S, Fan Y, Deng X, Zhou S, Mehta JL. PCSK9 expression in the ischaemic heart and its relationship to infarct size, cardiac function, and development of autophagy Cardiovasc Res. 2018 Nov 1;114(13):1738-1751.
10: Král T. Praluent (alirokumab) Vnitr Lek. 2020 Spring;66(5):96-100.

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