Psalmotoxin 1

Product Description

Psalmotoxin 1
Catalog number: MDP0796
CAS Number: 109770-29-8
Sequence: Glu-Asp-Cys-Ile-Pro-Lys-Trp-Lys-Gly-Cys-Val-Asn-Arg-His-Gly-Asp-Cys-Cys-Glu-Gly-Leu-Glu-Cys-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys-Val-Pro-Lys-Thr-Pro-Lys-Thr (Disulfide bonds between Cys3-Cys18, Cys10-Cys23, and Cys17-Cys33)
Amount: 100 ug
Molecular Weight: 4689.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Dibas A, Millar C, Al-Farra A, Yorio T. Neuroprotective Effects of Psalmotoxin-1, an Acid-Sensing Ion Channel (ASIC) Inhibitor, in Ischemia Reperfusion in Mouse Eyes Curr Eye Res. 2018 Jul;43(7):921-933.
2: Qadri YJ, Berdiev BK, Song Y, Lippton HL, Fuller CM, Benos DJ. Psalmotoxin-1 docking to human acid-sensing ion channel-1 J Biol Chem. 2009 Jun 26;284(26):17625-33.
3: Dawson RJ, Benz J, Stohler P, Tetaz T, Joseph C, Huber S, Schmid G, Hügin D, Pflimlin P, Trube G, Rudolph MG, Hennig M, Ruf A. Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1 Nat Commun. 2012 Jul 3;3:936.
4: Yang ZJ, Ni X, Carter EL, Kibler K, Martin LJ, Koehler RC. Neuroprotective effect of acid-sensing ion channel inhibitor psalmotoxin-1 after hypoxia-ischemia in newborn piglet striatum Neurobiol Dis. 2011 Aug;43(2):446-54.
5: Smith RN, Gonzales EB. Protons and Psalmotoxin-1 reveal nonproton ligand stimulatory sites in chicken acid-sensing ion channel: Implication for simultaneous modulation in ASICs Channels (Austin). 2014;8(1):49-61.
6: Chen X, Kalbacher H, Gründer S. Interaction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependent J Gen Physiol. 2006 Mar;127(3):267-76.
7: Chen X, Kalbacher H, Gründer S. The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity J Gen Physiol. 2005 Jul;126(1):71-9.
8: Yu H, Yang L, Liu L, Zhao X, Huang X. Molecular dynamics simulations investigate the mechanism of Psalmotoxin 1 regulating gating process of an acid-sensing ion channel 1a at pH 5.5 J Biomol Struct Dyn. 2018 Aug;36(10):2558-2566.
9: Bubien JK, Ji HL, Gillespie GY, Fuller CM, Markert JM, Mapstone TB, Benos DJ. Cation selectivity and inhibition of malignant glioma Na+ channels by Psalmotoxin 1 Am J Physiol Cell Physiol. 2004 Nov;287(5):C1282-91.
10: Chen Y, Zhu CJ, Zhu F, Dai BB, Song SJ, Wang ZQ, Feng YB, Ge JF, Zhou RP, Chen FH. Necrostatin-1 ameliorates adjuvant arthritis rat articular chondrocyte injury via inhibiting ASIC1a-mediated necroptosis Biochem Biophys Res Commun. 2018 Oct 12;504(4):843-850.

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