Protein Kinase A Inhibitor

Description

Protein Kinase A Inhibitor
Catalog number: B2012785
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 500 ug
Molecular Weight or Concentration: N/A
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: 2-8°C
Keywords: Protein Kinase A Inhibitor (6-22), amide
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Åberg E, Lund B, Pflug A, Gani OA, Rothweiler U, de Oliveira TM, Engh RA. Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool Biol Chem. 2012 Oct;393(10):1121-9.
2: Alam KA, Gani OASBM, Engh RA. Inhibitor binding to mutants of protein kinase A with GGGxxG and GxGxxA glycine-rich loop motifs J Mol Recognit. 2021 Apr;34(4):e2882.
3: Manschwetus JT, Bendzunas GN, Limaye AJ, Knape MJ, Herberg FW, Kennedy EJ. A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase_A Molecules. 2019 Apr 20;24(8):1567.
4: Liu Y, Chen J, Fontes SK, Bautista EN, Cheng Z. Physiological and pathological roles of protein kinase_A in the heart Cardiovasc Res. 2022 Jan 29;118(2):386-398.
5: Meng FN, Ying YL, Yang J, Long YT. A Wild-Type Nanopore Sensor for Protein_Kinase Activity Anal Chem. 2019 Aug 6;91(15):9910-9915.
6: Saito D, Imai M, Hasegawa S, Yamasaki M, Takahashi N. A splicing factor phosphorylated by protein kinase_A is increased in HL60 cells treated with retinoic acid Biochim Biophys Acta Mol Cell Res. 2022 Jan;1869(1):119142.
7: Müller J, Kirschner RA, Berndt JP, Wulsdorf T, Metz A, Hrdina R, Schreiner PR, Geyer A, Klebe G. Diamondoid Amino Acid-Based Peptide Kinase_A Inhibitor Analogues ChemMedChem. 2019 Mar 22;14(6):663-672.
8: Enns LC, Ladiges W. Protein kinase A signaling as an anti-aging target Ageing Res Rev. 2010 Jul;9(3):269-72.
9: Naviglio S, Caraglia M, Abbruzzese A, Chiosi E, Di Gesto D, Marra M, Romano M, Sorrentino A, Sorvillo L, Spina A, Illiano G. Protein kinase_A as a biological target in cancer therapy Expert Opin Ther Targets. 2009 Jan;13(1):83-92.
10: Vijayaraghavan S, Goueli SA, Davey MP, Carr DW. Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility J Biol Chem. 1997 Feb 21;272(8):4747-52.

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