Proangiotensin-12 (Rat)

Description

Catalog number: MDP0799
Name: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Tyr
Other name(s): Proangiotensin-12 (Rat)
Molecular Formula: C₇₇H₁₀₉N₁₉O₁₇
Molecular Mass: 1572.8
CAS #: 914910-73-9
Storage Temperature: -20 C
Indication for Use:
This product if for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use.

References:
1: Nagata S, Kato J, Sasaki K, Minamino N, Eto T, Kitamura K. Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system Biochem Biophys Res Commun. 2006 Dec 1;350(4):1026-31.
2: Nagata S, Kato J, Kuwasako K, Asami M, Kitamura K. Plasma and tissue concentrations of proangiotensin-12 in rats treated with inhibitors of the renin-angiotensin system Hypertens Res. 2012 Feb;35(2):234-8.
3: Varagic J, Trask AJ, Jessup JA, Chappell MC, Ferrario CM. New angiotensins J Mol Med (Berl). 2008 Jun;86(6):663-71.
4: Nagata S, Kato J, Kuwasako K, Kitamura K. Plasma and tissue levels of proangiotensin-12 and components of the renin-angiotensin system (RAS) following low- or high-salt feeding in rats Peptides. 2010 May;31(5):889-92.
5: Komatsu Y, Kida N, Nozaki N, Kuwasako K, Nagata S, Kitamura K, Kato J. Effects of proangiotensin-12 infused continuously over 14 days in conscious rats Eur J Pharmacol. 2012 May 15;683(1-3):186-9.
6: Prosser HC, Forster ME, Richards AM, Pemberton CJ. Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics Cardiovasc Res. 2009 Apr 1;82(1):40-50.
7: Bujak-Gizycka B, Olszanecki R, Suski M, Madek J, Stachowicz A, Korbut R. Angiotensinogen metabolism in rat aorta: robust formation of proangiotensin-12 J Physiol Pharmacol. 2010 Dec;61(6):679-82.
8: Li T, Zhang X, Cheng HJ, Zhang Z, Ahmad S, Varagic J, Li W, Cheng CP, Ferrario CM. Critical role of the chymase/angiotensin-(1-12) axis in modulating cardiomyocyte contractility Int J Cardiol. 2018 Aug 1;264:137-144.
9: Prosser HC, Richards AM, Forster ME, Pemberton CJ. Regional vascular response to ProAngiotensin-12 (PA12) through the rat arterial system Peptides. 2010 Aug;31(8):1540-5.
10: Reyes S, Cheng CP, Roberts DJ, Yamashita T, Ahmad S, VonCannon JL, Wright KN, Dell’Italia LJ, Varagic J, Ferrario CM. Angiotensin-(1-12)/chymase axis modulates cardiomyocyte L-type calcium currents in rats expressing human angiotensinogen Int J Cardiol. 2019 Dec 15;297:104-110.

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