Phospho-ATF2 (Thr71) Rabbit FITC Conjugate

Product Description

Phospho-ATF2 (Thr71) Rabbit FITC Conjugate
Catalog number: B2018641
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 ug
Molecular Weight or Concentration: N/A
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: 2-8°C
Keywords: Cyclic AMP-dependent transcription factor ATF-2, Activating transcription factor 2, Cyclic AMP-responsive element-binding protein 2, CREB-2, HB16, CREB2, CREBP1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Rudraraju B, Droog M, Abdel-Fatah TM, Zwart W, Giannoudis A, Malki MI, Moore D, Patel H, Shaw J, Ellis IO, Chan S, Brooke GN, Nevedomskaya E, Lo Nigro C, Carroll J, Coombes RC, Bevan C, Ali S, Palmieri C. Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer Breast Cancer Res Treat. 2014 Sep;147(2):295-309.
2: Walton M, Woodgate AM, Sirimanne E, Gluckman P, Dragunow M. ATF-2 phosphorylation in apoptotic neuronal death Brain Res Mol Brain Res. 1998 Dec 10;63(1):198-204.
3: Huang J, Ledford KJ, Pitkin WB, Russo L, Najjar SM, Siragy HM. Targeted deletion of murine CEACAM 1 activates PI3K-Akt signaling and contributes to the expression of (Pro)renin receptor via CREB family and NF-κB transcription factors Hypertension. 2013 Aug;62(2):317-23.
4: Ouwens DM, de Ruiter ND, van der Zon GC, Carter AP, Schouten J, van der Burgt C, Kooistra K, Bos JL, Maassen JA, van Dam H. Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38 EMBO J. 2002 Jul 15;21(14):3782-93.
5: Baan B, van der Zon GC, Maassen JA, Ouwens DM. The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells Mol Cell Endocrinol. 2009 Nov 13;311(1-2):94-100.
6: Diring J, Camuzeaux B, Donzeau M, Vigneron M, Rosa-Calatrava M, Kedinger C, Chatton B. A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity PLoS One. 2011;6(8):e23351.
7: Baan B, van Dam H, van der Zon GC, Maassen JA, Ouwens DM. The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2 Mol Endocrinol. 2006 Aug;20(8):1786-95.
8: Fuchs SY, Tappin I, Ronai Z. Stability of the ATF2 transcription factor is regulated by phosphorylation and dephosphorylation J Biol Chem. 2000 Apr 28;275(17):12560-4.
9: Huang Q, Du X, He X, Yu Q, Hu K, Breitwieser W, Shen Q, Ma S, Li M. JNK-mediated activation of ATF2 contributes to dopaminergic neurodegeneration in the MPTP mouse model of Parkinson’s disease Exp Neurol. 2016 Mar;277:296-304.
10: Zhu F, Zhang Y, Bode AM, Dong Z. Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells Carcinogenesis. 2004 Oct;25(10):1847-52.

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