p70 S6 Kinase Substrate


Catalog Number: B2011468 (1 mg)
p70 S6 Kinase Substrate is a high quality substrate for p70 ribosomal S6 kinase. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2011468 Categories: ,


p70 S6 Kinase Substrate
Catalog number: B2011468
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1115.4 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: p70 S6 Kinase Substrate [KKRNRTLTV]
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Fan Y, Cheng Y, Li Y, Chen B, Wang Z, Wei T, Zhang H, Guo Y, Wang Q, Wei Y, Chen F, Sha J, Guo X, Wang L. Phosphoproteomic Analysis of Neonatal Regenerative Myocardium Revealed Important Roles of Checkpoint Kinase 1 via Activating Mammalian Target of Rapamycin C1/Ribosomal Protein S6 Kinase b-1 Pathway Circulation. 2020 May 12;141(19):1554-1569.
2: Tang G, Li S, Zhang C, Chen H, Wang N, Feng Y. Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management Acta Pharm Sin B. 2021 Sep;11(9):2749-2767.
3: Yang H, Rudge DG, Koos JD, Vaidialingam B, Yang HJ, Pavletich NP. mTOR kinase structure, mechanism and regulation Nature. 2013 May 9;497(7448):217-23.
4: Li C, Ma B, Chen J, Jeong Y, Xu X. Astaxanthin Inhibits p70 S6 Kinase 1 Activity to Sensitize Insulin Signaling Mar Drugs. 2020 Sep 28;18(10):495.
5: Theodoropoulou M, Stalla GK. Somatostatin receptors: from signaling to clinical practice Front Neuroendocrinol. 2013 Aug;34(3):228-52.
6: Artemenko M, Zhong SSW, To SKY, Wong AST. p70 S6 kinase as a therapeutic target in cancers: More than just an mTOR effector Cancer Lett. 2022 Jun 1;535:215593.
7: Yang H, Jiang X, Li B, Yang HJ, Miller M, Yang A, Dhar A, Pavletich NP. Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40 Nature. 2017 Dec 21;552(7685):368-373.
8: Ip CK, Wong AS. Exploiting p70 S6 kinase as a target for ovarian cancer Expert Opin Ther Targets. 2012 Jun;16(6):619-30.
9: Bhatt AP, Wong JP, Weinberg MS, Host KM, Giffin LC, Buijnink J, van Dijk E, Izumiya Y, Kung HJ, Temple BR, Damania B. A viral kinase mimics S6 kinase to enhance cell proliferation Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7876-81.
10: Dhar R, Persaud SD, Mireles JR, Basu A. Proteolytic cleavage of p70 ribosomal S6 kinase by caspase-3 during DNA damage-induced apoptosis Biochemistry. 2009 Feb 24;48(7):1474-80.

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