Orexin-A (Human)

Product Description

Orexin-A (Human)
Catalog number: MDP0717
CAS Number: 144409-99-4
Sequence: Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bonds between Cys6-Cys12 and Cys7-Cys14)
Amount: 100 ug
Molecular Weight: 3560.8 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Nepovimova E, Janockova J, Misik J, Kubik S, Stuchlik A, Vales K, Korabecny J, Mezeiova E, Dolezal R, Soukup O, Kobrlova T, Pham NL, Nguyen TD, Konecny J, Kuca K. Orexin supplementation in narcolepsy treatment: A review Med Res Rev. 2019 May;39(3):961-975.
2: Mahoney CE, Cogswell A, Koralnik IJ, Scammell TE. The neurobiological basis of narcolepsy Nat Rev Neurosci. 2019 Feb;20(2):83-93.
3: Imperatore R, Palomba L, Cristino L. Role of Orexin-A in Hypertension and Obesity Curr Hypertens Rep. 2017 Apr;19(4):34.
4: Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U, Khatami R, Koning F, Kornum BR, Lammers GJ, Liblau RS, Luppi PH, Mayer G, Pollmächer T, Sakurai T, Sallusto F, Scammell TE, Tafti M, Dauvilliers Y. Narcolepsy – clinical spectrum, aetiopathophysiology, diagnosis and treatment Nat Rev Neurol. 2019 Sep;15(9):519-539.
5: Toor B, Ray LB, Pozzobon A, Fogel SM. Sleep, Orexin and Cognition Front Neurol Neurosci. 2021;45:38-51.
6: Wu X, Xue T, Chen Z, Wang Z, Chen G. Orexin Receptor Antagonists and Insomnia Curr Psychiatry Rep. 2022 Oct;24(10):509-521.
7: Xu D, Kong T, Shao Z, Liu M, Zhang R, Zhang S, Kong Q, Chen J, Cheng B, Wang C. Orexin-A alleviates astrocytic apoptosis and inflammation via inhibiting OX1R-mediated NF-κB and MAPK signaling pathways in cerebral ischemia/reperfusion injury Biochim Biophys Acta Mol Basis Dis. 2021 Nov 1;1867(11):166230.
8: Duffet L, Kosar S, Panniello M, Viberti B, Bracey E, Zych AD, Radoux-Mergault A, Zhou X, Dernic J, Ravotto L, Tsai YC, Figueiredo M, Tyagarajan SK, Weber B, Stoeber M, Gogolla N, Schmidt MH, Adamantidis AR, Fellin T, Burdakov D, Patriarchi T. A genetically encoded sensor for in vivo imaging of orexin neuropeptides Nat Methods. 2022 Feb;19(2):231-241.
9: Barateau L, Pizza F, Plazzi G, Dauvilliers Y. Narcolepsy J Sleep Res. 2022 Aug;31(4):e13631.
10: Kukkonen JP. Orexin/Hypocretin Signaling Curr Top Behav Neurosci. 2017;33:17-50.

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