[Nle8,18,Tyr34]-Parathyroid Hormone (Human, 1-34 Amide)

Product Description

[Nle8,18,Tyr34]-Parathyroid Hormone (Human, 1-34 Amide)
Catalog number: MDP0565
CAS Number: 104339-66-4
Sequence: Ser-Val-Ser-Glu-Ile-Gln-Leu-Nle-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Nle-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Tyr-NH2 (Nle: L-Norleucine)
Amount: 500 ug
Molecular Weight: 4096.4 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Dresner-Pollak R, Yang QM, Behar V, Nakamoto C, Chorev M, Rosenblatt M. Evaluation in vivo of a potent parathyroid hormone antagonist: [Nle8,18,D-Trp12,Tyr34]bPTH(7-34)NH2 J Bone Miner Res. 1996 Aug;11(8):1061-5.
2: Singh AT, Kunnel JG, Strieleman PJ, Stern PH. Parathyroid hormone (PTH)-(1-34), [Nle(8,18),Tyr34]PTH-(3-34) amide, PTH-(1-31) amide, and PTH-related peptide-(1-34) stimulate phosphatidylcholine hydrolysis in UMR-106 osteoblastic cells: comparison with effects of phorbol 12,13-dibutyrate Endocrinology. 1999 Jan;140(1):131-7.
3: Nakai M, Fukase M, Yamaguchi T, Tsukamoto T, Fujii N, Fujita T. Human PTH-(3-34) inhibited the effects of human parathyroid hormone-related protein on phosphate uptake in a cultured renal cell line (OK cells) J Bone Miner Res. 1990 Oct;5(10):995-1002.
4: Jüppner H. Functional properties of the PTH/PTHrP receptor Bone. 1995 Aug;17(2 Suppl):39S-42S.
5: Schipani E, Karga H, Karaplis AC, Potts JT Jr, Kronenberg HM, Segre GV, Abou-Samra AB, Jüppner H. Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor Endocrinology. 1993 May;132(5):2157-65.
6: Jüppner H, Schipani E, Bringhurst FR, McClure I, Keutmann HT, Potts JT Jr, Kronenberg HM, Abou-Samra AB, Segre GV, Gardella TJ. The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34) Endocrinology. 1994 Feb;134(2):879-84.
7: Inomata N, Akiyama M, Kubota N, Jüppner H. Characterization of a novel parathyroid hormone (PTH) receptor with specificity for the carboxyl-terminal region of PTH-(1-84) Endocrinology. 1995 Nov;136(11):4732-40.
8: Holick MF, Ray S, Chen TC, Tian X, Persons KS. A parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8014-6.
9: García-Ocaña A, De Miguel F, Peñaranda C, Albar JP, Sarasa JL, Esbrit P. Parathyroid hormone-related protein is an autocrine modulator of rabbit proximal tubule cell growth J Bone Miner Res. 1995 Dec;10(12):1875-84.
10: Lafond J, Auger D, Fortier J, Brunette MG. Parathyroid hormone receptor in human placental syncytiotrophoblast brush border and basal plasma membranes Endocrinology. 1988 Dec;123(6):2834-40.

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