N-acetyl-S-(trichlorovinyl)-L-Cysteine

Product Description

N-acetyl-S-(trichlorovinyl)-L-Cysteine
Catalog number: B2017551
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 292.6
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: N/A
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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2: Covington TR, Robinan Gentry P, Van Landingham CB, Andersen ME, Kester JE, Clewell HJ. The use of Markov chain Monte Carlo uncertainty analysis to support a Public Health Goal for perchloroethylene Regul Toxicol Pharmacol. 2007 Feb;47(1):1-18.
3: Dekant W, Metzler M, Henschler D. Identification of S-1,2,2-trichlorovinyl-N-acetylcysteine as a urinary metabolite of tetrachloroethylene: bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity J Biochem Toxicol. 1986 Jun;1(2):57-72.
4: Birner G, Rutkowska A, Dekant W. N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine and 2,2,2-trichloroethanol: two novel metabolites of tetrachloroethene in humans after occupational exposure Drug Metab Dispos. 1996 Jan;24(1):41-8.
5: Völkel W, Friedewald M, Lederer E, Pähler A, Parker J, Dekant W. Biotransformation of perchloroethene: dose-dependent excretion of trichloroacetic acid, dichloroacetic acid, and N-acetyl-S-(trichlorovinyl)-L-cysteine in rats and humans after inhalation Toxicol Appl Pharmacol. 1998 Nov;153(1):20-7.
6: Bartels MJ. Quantitation of the tetrachloroethylene metabolite N-acetyl-S-(trichlorovinyl)cysteine in rat urine via negative ion chemical ionization gas chromatography/tandem mass spectrometry Biol Mass Spectrom. 1994 Nov;23(11):689-94.
7: Vamvakas S, Dekant W, Berthold K, Schmidt S, Wild D, Henschler D. Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates Biochem Pharmacol. 1987 Sep 1;36(17):2741-8.
8: Völkel W, Pähler A, Dekant W. Gas chromatography-negative ion chemical ionization mass spectrometry as a powerful tool for the detection of mercapturic acids and DNA and protein adducts as biomarkers of exposure to halogenated olefins J Chromatogr A. 1999 Jun 25;847(1-2):35-46.
9: Luo YS, Cichocki JA, McDonald TJ, Rusyn I. Simultaneous detection of the tetrachloroethylene metabolites S-(1,2,2-trichlorovinyl) glutathione, S-(1,2,2-trichlorovinyl)-L-cysteine, and N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine in multiple mouse tissues via ultra-high performance liquid chromatography electrospray ionization tandem mass spectrometry J Toxicol Environ Health A. 2017;80(9):513-524.
10: Cichocki JA, Luo YS, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice Toxicol Sci. 2019 Jan 1;167(1):126-137.

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