MMP-13 Substrate, Fluorogenic

Product Description

MMP-13 Substrate, Fluorogenic
Catalog number: B2014068
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 2.5 mg
Molecular Weight or Concentration: 1100.1 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Substrate, Fluorogenic, Collagenase-3 Substrate, Fluorogenic
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Lamort AS, Gravier R, Laffitte A, Juliano L, Zani ML, Moreau T. New insights into the substrate specificity of macrophage elastase MMP-12 Biol Chem. 2016 May;397(5):469-84.
2: Mynarczyk G, Kudelski J, Darewicz B, Bruczko-Goralewska M, Romanowicz L. Suppressed Expression but Not Activity of Collagenases MMP-1 and MMP-13 in Human Renal Carcinoma Pathobiology. 2019;86(4):201-207.
3: Beekman B, Drijfhout JW, Ronday HK, TeKoppele JM. Fluorogenic MMP activity assay for plasma including MMPs complexed to alpha 2-macroglobulin Ann N Y Acad Sci. 1999 Jun 30;878:150-8.
4: Chopra A. Cy5.5-Conjugated matrix metalloproteinase cleavable peptide nanoprobe 2012 Mar 19 [updated 2012 Apr 12]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 20042013.
5: Lauer-Fields JL, Fields GB. Triple-helical peptide analysis of collagenolytic protease activity Biol Chem. 2002 Jul-Aug;383(7-8):1095-105.
6: Robichaud TK, Steffensen B, Fields GB. Exosite interactions impact matrix metalloproteinase collagen specificities J Biol Chem. 2011 Oct 28;286(43):37535-42.
7: Lee S, Park K, Lee SY, Ryu JH, Park JW, Ahn HJ, Kwon IC, Youn IC, Kim K, Choi K. Dark quenched matrix metalloproteinase fluorogenic probe for imaging osteoarthritis development in vivo Bioconjug Chem. 2008 Sep;19(9):1743-7.
8: Neumann U, Kubota H, Frei K, Ganu V, Leppert D. Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme Anal Biochem. 2004 May 15;328(2):166-73.
9: Lauer-Fields JL, Broder T, Sritharan T, Chung L, Nagase H, Fields GB. Kinetic analysis of matrix metalloproteinase activity using fluorogenic triple-helical substrates Biochemistry. 2001 May 15;40(19):5795-803.
10: Riley GP, Curry V, DeGroot J, van El B, Verzijl N, Hazleman BL, Bank RA. Matrix metalloproteinase activities and their relationship with collagen remodelling in tendon pathology Matrix Biol. 2002 Mar;21(2):185-95.

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