LL-37 (Human)

Product Description

LL-37 (Human)
Catalog number: MDP0805
CAS Number: N/A
Sequence: Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
Amount: 100 ug
Molecular Weight: 4493.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Chen X, Zou X, Qi G, Tang Y, Guo Y, Si J, Liang L. Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer Cell Physiol Biochem. 2018;47(3):1060-1073.
2: Wang G, Narayana JL, Mishra B, Zhang Y, Wang F, Wang C, Zarena D, Lushnikova T, Wang X. Design of Antimicrobial Peptides: Progress Made with Human Cathelicidin LL-37 Adv Exp Med Biol. 2019;1117:215-240.
3: Ridyard KE, Overhage J. The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent Antibiotics (Basel). 2021 May 29;10(6):650.
4: Aloul KM, Nielsen JE, Defensor EB, Lin JS, Fortkort JA, Shamloo M, Cirillo JD, Gombart AF, Barron AE. Upregulating Human Cathelicidin Antimicrobial Peptide LL-37 Expression May Prevent Severe COVID-19 Inflammatory Responses and Reduce Microthrombosis Front Immunol. 2022 May 12;13:880961.
5: Wei X, Zhang L, Yang Y, Hou Y, Xu Y, Wang Z, Su H, Han F, Han J, Liu P, Hu S, Koci MD, Sun X, Zhang C. LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity Cell Rep. 2022 May 31;39(9):110880.
6: Jacobsen AS, Jenssen H. Human cathelicidin LL-37 prevents bacterial biofilm formation Future Med Chem. 2012 Aug;4(12):1587-99.
7: Suzuki K, Ohkuma M, Someya A, Mita T, Nagaoka I. Human Cathelicidin Peptide LL-37 Induces Cell Death in Autophagy-Dysfunctional Endothelial Cells J Immunol. 2022 May 1;208(9):2163-2172.
8: Méndez-Samperio P. The human cathelicidin hCAP18/LL-37: a multifunctional peptide involved in mycobacterial infections Peptides. 2010 Sep;31(9):1791-8.
9: Chieosilapatham P, Ikeda S, Ogawa H, Niyonsaba F. Tissue-specific Regulation of Innate Immune Responses by Human Cathelicidin LL-37 Curr Pharm Des. 2018;24(10):1079-1091.
10: Sánchez-Peña FJ, Romero-Tlalolini MLÁ, Torres-Aguilar H, Cruz-Hernández DS, Baltiérrez-Hoyos R, Sánchez-Aparicio SR, Aquino-Domínguez AS, Aguilar-Ruiz SR. LL-37 Triggers Antimicrobial Activity in Human Platelets Int J Mol Sci. 2023 Feb 1;24(3):2816.

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