LEAP-2 (Human)

Product Description

LEAP-2 (Human)
Catalog number: MDP0769
CAS Number: 909409-86-5
Sequence: Met-Thr-Pro-Phe-Trp-Arg-Gly-Val-Ser-Leu-Arg-Pro-Ile-Gly-Ala-Ser-Cys-Arg-Asp-Asp-Ser-Glu-Cys-Ile-Thr-Arg-Leu-Cys-Arg-Lys-Arg-Arg-Cys-Ser-Leu-Ser-Val-Ala-Gln-Glu (Disulfide bonds between Cys17-Cys28 and Cys23-Cys33)
Amount: 100 ug
Molecular Weight: 4581.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Lu X, Huang L, Huang Z, Feng D, Clark RJ, Chen C. LEAP-2: An Emerging Endogenous Ghrelin Receptor Antagonist in the Pathophysiology of Obesity Front Endocrinol (Lausanne). 2021 Aug 24;12:717544.
2: Barja-Fernández S, Lugilde J, Castelao C, Vázquez-Cobela R, Seoane LM, Diéguez C, Leis R, Tovar S. Circulating LEAP-2 is associated with puberty in girls Int J Obes (Lond). 2021 Mar;45(3):502-514.
3: Garcés MF, Buell-Acosta JD, Ángel-Müller E, Parada-Baños AJ, Acosta-Alvarez J, Saavedra-López HF, Franco-Vega R, Maldonado-Acosta LM, Escobar-Cordoba F, Vásquez-Romero K, Lacunza E, Caminos-Cepeda SA, Nogueiras R, Diéguez C, Ruiz-Parra AI, Caminos JE. Study of the Ghrelin/LEAP-2 Ratio in Humans and Rats during Different Phases of Pregnancy Int J Mol Sci. 2022 Aug 23;23(17):9514.
4: Al-Massadi O, Müller T, Tschöp M, Diéguez C, Nogueiras R. Ghrelin and LEAP-2: Rivals in Energy Metabolism Trends Pharmacol Sci. 2018 Aug;39(8):685-694.
5: Vergani E, Bruno C, Gavotti C, Aversa LS, Martire M, Mancini A, Currò D. LEAP-2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study IUBMB Life. 2021 Jul;73(7):978-984.
6: Howard A, Townes C, Milona P, Nile CJ, Michailidis G, Hall J. Expression and functional analyses of liver expressed antimicrobial peptide-2 (LEAP-2) variant forms in human tissues Cell Immunol. 2010;261(2):128-33.
7: Ragland TJ, Malin SK. Plasma LEAP-2 Following a Low-Calorie Diet with or without Interval Exercise in Women with Obesity Nutrients. 2023 Jan 28;15(3):655.
8: Bogefors J, Kvarnhammar AM, Millrud CR, Georén SK, Cardell LO. LEAP-2, LL-37 and RNase7 in tonsillar tissue: downregulated expression in seasonal allergic rhinitis Pathog Dis. 2014 Oct;72(1):55-60.
9: Hocquellet A, Odaert B, Cabanne C, Noubhani A, Dieryck W, Joucla G, Le Senechal C, Milenkov M, Chaignepain S, Schmitter JM, Claverol S, Santarelli X, Dufourc EJ, Bonneu M, Garbay B, Costaglioli P. Structure-activity relationship of human liver-expressed antimicrobial peptide 2 Peptides. 2010 Jan;31(1):58-66.
10: Gupta D, Ogden SB, Shankar K, Varshney S, Zigman JM. “A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes” Mol Metab. 2021 Apr;46:101128.

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