Insulin (Human)

Product Description

Insulin (Human)
Catalog number: MDP0456
CAS Number: 97825-07-5
Sequence: A-chain:Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn B-chain:Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Thr (Disulfide bonds between CysA6-CysA11, CysA7-CysB7, and CysA20-CysB19)
Amount: 500 ug
Molecular Weight: 5807.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Riggs AD. Making, Cloning, and the Expression of Human Insulin Genes in Bacteria: The Path to Humulin Endocr Rev. 2021 May 25;42(3):374-380.
2: Wilson LM, Castle JR. Recent Advances in Insulin Therapy Diabetes Technol Ther. 2020 Dec;22(12):929-936.
3: Davidson MB. The Case for Using Human Insulin Am J Med. 2020 Feb;133(2):e23-e24.
4: Nishimura E, Pridal L, Glendorf T, Hansen BF, Hubálek F, Kjeldsen T, Kristensen NR, Lützen A, Lyby K, Madsen P, Pedersen TÅ, Ribel-Madsen R, Stidsen CE, Haahr H. Molecular and pharmacological characterization of insulin icodec: a new basal insulin analog designed for once-weekly dosing BMJ Open Diabetes Res Care. 2021 Aug;9(1):e002301.
5: Toledano Y, Hadar E, Hod M. Safety of insulin analogues as compared with human insulin in pregnancy Expert Opin Drug Saf. 2016 Jul;15(7):963-73.
6: Lee SH, Yoon KH. A Century of Progress in Diabetes Care with Insulin: A History of Innovations and Foundation for the Future Diabetes Metab J. 2021 Sep;45(5):629-640.
7: Wang M, Wang C, Ren S, Pan J, Wang Y, Shen Y, Zeng Z, Cui H, Zhao X. Versatile Oral Insulin Delivery Nanosystems: From Materials to Nanostructures Int J Mol Sci. 2022 Mar 20;23(6):3362.
8: Jin X, Zeng L, Zhang S, He S, Ren Y, Chen Y, Wei L, Wang L, Li H, Cheng J, Lu Y. Human insulin versus porcine insulin in rhesus monkeys with diabetes mellitus J Med Primatol. 2013 Feb;42(1):1-9.
9: Vinther TN, Kjeldsen TB, Jensen KJ, Hubálek F. The road to the first, fully active and more stable human insulin variant with an additional disulfide bond J Pept Sci. 2015 Nov;21(11):797-806.
10: Larsen JK, Larsen MR, Birk JB, Steenberg DE, Hingst JR, Højlund K, Chadt A, Al-Hasani H, Deshmukh AS, Wojtaszewski JFP, Kjøbsted R. Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle Diabetes. 2022 May 1;71(5):906-920.

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