L17E Cytosolic Delivery Peptide

Product Description

L17E Cytosolic Delivery Peptide
Catalog number: MDP0292
CAS Number: 37691-11-5
Sequence: Ile-Trp-Leu-Thr-Ala-Leu-Lys-Phe-Leu-Gly-Lys-His-Ala-Ala-Lys-His-Glu-Ala-Lys-Gln-Gln-Leu-Ser-Lys-Leu-NH2
Amount: 500 ug
Molecular Weight: 2859.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Nomura Y, Sakamoto K, Akishiba M, Iwata T, Hirose H, Futaki S. Improved cytosolic delivery of macromolecules through dimerization of attenuated lytic peptides Bioorg Med Chem Lett. 2020 Sep 1;30(17):127362.
2: Shinga K, Iwata T, Murata K, Daitoku Y, Michibata J, Arafiles JVV, Sakamoto K, Akishiba M, Takatani-Nakase T, Mizuno S, Sugiyama F, Imanishi M, Futaki S. L17ER4: A cell-permeable attenuated cationic amphiphilic lytic peptide Bioorg Med Chem. 2022 May 1;61:116728.
3: Becker B, Englert S, Schneider H, Yanakieva D, Hofmann S, Dombrowsky C, Macarrón Palacios A, Bitsch S, Elter A, Meckel T, Kugler B, Schirmacher A, Avrutina O, Diederichsen U, Kolmar H. Multivalent dextran hybrids for efficient cytosolic delivery of biomolecular cargoes J Pept Sci. 2021 Apr;27(4):e3298.
4: Iwata T, Hirose H, Sakamoto K, Hirai Y, Arafiles JVV, Akishiba M, Imanishi M, Futaki S. Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides Angew Chem Int Ed Engl. 2021 Sep 1;60(36):19804-19812.
5: Akishiba M, Takeuchi T, Kawaguchi Y, Sakamoto K, Yu HH, Nakase I, Takatani-Nakase T, Madani F, Gräslund A, Futaki S. Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide Nat Chem. 2017 Aug;9(8):751-761.
6: Feng R, Ni R, Chau Y. Fusogenic peptide modification to enhance gene delivery by peptide-DNA nano-coassemblies Biomater Sci. 2022 Sep 13;10(18):5116-5120.
7: Zhan Q, Yi K, Qi H, Li S, Li X, Wang Q, Wang Y, Liu C, Qiu M, Yuan X, Zhao J, Hou X, Kang C. Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy Theranostics. 2020 Jun 22;10(17):7889-7905.
8: Du W, Du S, Dong X, Bai H, Jiang J, Hao S, Yang F, Xiao Q, Zhang B, Ge J, Gao L, Li L, Yao SQ, Huang W. Biodegradable silica nanocapsules enable efficient nuclear-targeted delivery of native proteins for cancer therapy Biomaterials. 2023 Mar;294:122000.
9: Akishiba M, Futaki S. Inducible Membrane Permeabilization by Attenuated Lytic Peptides: A New Concept for Accessing Cell Interiors through Ruffled Membranes Mol Pharm. 2019 Jun 3;16(6):2540-2548.
10: Lam P, Steinmetz NF. Delivery of siRNA therapeutics using cowpea chlorotic mottle virus-like particles Biomater Sci. 2019 Aug 1;7(8):3138-3142.

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