Human CRYM Protein

Description

Human CRYM Protein
Catalog number: B2012041
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Mu crystallin homolog protein, NADP regulated thyroid hormone binding protein protein, DFNA40 protein, Crystallin mu CRYM protein, OTTHUMP00000115878., DFNA 40 protein, THBP protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Kinney CJ, Bloch RJ. µ-Crystallin: A thyroid hormone binding protein Endocr Regul. 2021 May 21;55(2):89-102.
2: Kinney CJ, O’Neill A, Noland K, Huang W, Muriel J, Lukyanenko V, Kane MA, Ward CW, Collier AF, Roche JA, McLenithan JC, Reed PW, Bloch RJ. μ-Crystallin in Mouse Skeletal Muscle Promotes a Shift from Glycolytic toward Oxidative Metabolism Curr Res Physiol. 2021 Feb 9;4:47-59.
3: Francelle L, Galvan L, Gaillard MC, Guillermier M, Houitte D, Bonvento G, Petit F, Jan C, Dufour N, Hantraye P, Elalouf JM, De Chaldée M, Déglon N, Brouillet E. Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington’s disease Hum Mol Genet. 2015 Mar 15;24(6):1563-73.
4: Aksoy O, Pencik J, Hartenbach M, Moazzami AA, Schlederer M, Balber T, Varady A, Philippe C, Baltzer PA, Mazumder B, Whitchurch JB, Roberts CJ, Haitel A, Herac M, Susani M, Mitterhauser M, Marculescu R, Stangl-Kremser J, Hassler MR, Kramer G, Shariat SF, Turner SD, Tichy B, Oppelt J, Pospisilova S, Hartenbach S, Tangermann S, Egger G, Neubauer HA, Moriggl R, Culig Z, Greiner G, Hoermann G, Hacker M, Heery DM, Merkel O, Kenner L. Thyroid and androgen receptor signaling are antagonized by μ-Crystallin in prostate cancer Int J Cancer. 2021 Feb 1;148(3):731-747.
5: Cheng Z, Sun L, He J, Gong W. Crystal structure of human micro-crystallin complexed with NADPH Protein Sci. 2007 Feb;16(2):329-35.
6: Hommyo R, Suzuki SO, Abolhassani N, Hamasaki H, Shijo M, Maeda N, Honda H, Nakabeppu Y, Iwaki T. Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis Neuropathology. 2018 Jun;38(3):247-259.
7: Abe S, Katagiri T, Saito-Hisaminato A, Usami S, Inoue Y, Tsunoda T, Nakamura Y. Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues Am J Hum Genet. 2003 Jan;72(1):73-82.
8: Oshima A, Suzuki S, Takumi Y, Hashizume K, Abe S, Usami S. CRYM mutations cause deafness through thyroid hormone binding properties in the fibrocytes of the cochlea J Med Genet. 2006 Jun;43(6):e25.
9: Malinowska K, Cavarretta IT, Susani M, Wrulich OA, Uberall F, Kenner L, Culig Z. Identification of mu-crystallin as an androgen-regulated gene in human prostate cancer Prostate. 2009 Jul 1;69(10):1109-18.
10: Hallen A, Cooper AJ. Reciprocal Control of Thyroid Binding and the Pipecolate Pathway in the Brain Neurochem Res. 2017 Jan;42(1):217-243.

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