Human CPOX Protein


Catalog Number: B2012018 (100 µg)
Human CPOX Protein is a high quality recombinant human CPOX protein His tagged and expressed in E.coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Human CPOX Protein
Catalog number: B2012018
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Coproporphyrinogen-III oxidase protein, mitochondrial precursor protein, CPO protein, CPX protein, HCP protein, CPOX
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Pustogarov N, Panteleev D, Goryaynov SA, Ryabova AV, Rybalkina EY, Revishchin A, Potapov AA, Pavlova G. Hiding in the Shadows: CPOX Expression and 5-ALA Induced Fluorescence in Human Glioma Cells Mol Neurobiol. 2017 Sep;54(7):5699-5708.
2: Módis K, Ramanujam VS, Govar AA, Lopez E, Anderson KE, Wang R, Szabo C. Cystathionine-γ-lyase (CSE) deficiency increases erythropoiesis and promotes mitochondrial electron transport via the upregulation of coproporphyrinogen III oxidase and consequent stimulation of heme biosynthesis Biochem Pharmacol. 2019 Nov;169:113604.
3: Li T, Woods JS. Cloning, expression, and biochemical properties of CPOX4, a genetic variant of coproporphyrinogen oxidase that affects susceptibility to mercury toxicity in humans Toxicol Sci. 2009 Jun;109(2):228-36.
4: Oshima Y, Cartier E, Boyman L, Verhoeven N, Polster BM, Huang W, Kane M, Lederer WJ, Karbowski M. Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination J Cell Biol. 2021 Jun 7;220(6):e202006043.
5: Borrero Corte MJ, Jara Rubio F, Morán Jiménez MJ, Díaz Díaz S, Castelbón Fernandez FJ, García Pastor I, Enríquez de Salamanca R, Méndez M. Molecular analysis of 19 Spanish patients with mixed porphyrias Eur J Med Genet. 2019 Dec;62(12):103589.
6: Hong S, Dobricic V, Ohlei O, Bos I, Vos SJB, Prokopenko D, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Gabel S, Scheltens P, Teunissen CE, Engelborghs S, Frisoni G, Blin O, Richardson JC, Bordet R; Alzheimer’s Disease Neuroimaging Initiative (ADNI), Lleó A, Alcolea D, Popp J, Clark C, Peyratout G, Martinez-Lage P, Tainta M, Dobson RJB, Legido-Quigley C, Sleegers K, Van Broeckhoven C, Tanzi RE, Ten Kate M, Wittig M, Franke A, Lill CM, Barkhof F, Lovestone S, Streffer J, Zetterberg H, Visser PJ, Bertram L. TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer’s disease biomarker levels Alzheimers Dement. 2021 Oct;17(10):1628-1640.
7: Taketani S, Furukawa T, Furuyama K. Expression of coproporphyrinogen oxidase and synthesis of hemoglobin in human erythroleukemia K562 cells Eur J Biochem. 2001 Mar;268(6):1705-11.
8: Oshima Y, Verhoeven N, Cartier E, Karbowski M. The OMM-severed and IMM-ubiquitinated mitochondria are intermediates of mitochondrial proteotoxicity-induced autophagy in PRKN/parkin-deficient cells Autophagy. 2021 Nov;17(11):3884-3886.
9: Kim DH, Hino R, Adachi Y, Kobori A, Taketani S. The enzyme engineering of mutant homodimer and heterodimer of coproporphyinogen oxidase contributes to new insight into hereditary coproporphyria and harderoporphyria J Biochem. 2013 Dec;154(6):551-9.
10: Nikonoshina NA, Zaitseva NV, Dolgikh ОV. Peculiarities of Immune Regulation in Men of Perm Region with Atherosclerosis Related to Polymorphism of Candidate Genes Bull Exp Biol Med. 2021 Mar;170(5):645-648.

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