Human CLIC2 Protein


Catalog Number: B2011974 (100 µg)
Human CLIC2 Protein is a high quality recombinant human CLIC2 protein His tagged and expressed in E.coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Human CLIC2 Protein
Catalog number: B2011974
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 µg
Molecular Weight or Concentration: 1 mg/mL
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: CLIC 2 protein, CLIC2b protein, CLIC-2 protein, CLIC 2, XAP121 protein, CLIC2, CLIC-2, Chloride intracellular channel protein 2 protein
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Ueno Y, Ozaki S, Umakoshi A, Yano H, Choudhury ME, Abe N, Sumida Y, Kuwabara J, Uchida R, Islam A, Ogawa K, Ishimaru K, Yorozuya T, Kunieda T, Watanabe Y, Takada Y, Tanaka J. Chloride intracellular channel protein 2 in cancer and non-cancer human tissues: relationship with tight junctions Tissue Barriers. 2019;7(1):1593775.
2: Cromer BA, Gorman MA, Hansen G, Adams JJ, Coggan M, Littler DR, Brown LJ, Mazzanti M, Breit SN, Curmi PM, Dulhunty AF, Board PG, Parker MW. Structure of the Janus protein human CLIC2 J Mol Biol. 2007 Nov 30;374(3):719-31.
3: Zeng J, Li Z, Lui EY, Lam SH, Swaminathan K. Tilapia and human CLIC2 structures are highly conserved Biochem Biophys Res Commun. 2018 Jan 8;495(2):1752-1757.
4: Ozaki S, Umakoshi A, Yano H, Ohsumi S, Sumida Y, Hayase E, Usa E, Islam A, Choudhury ME, Nishi Y, Yamashita D, Ohtsuka Y, Nishikawa M, Inoue A, Suehiro S, Kuwabara J, Watanabe H, Takada Y, Watanabe Y, Nakano I, Kunieda T, Tanaka J. Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis Neoplasia. 2021 Aug;23(8):754-765.
5: Huang W, Hu C, Zeng H, Li P, Guo L, Zeng X, Liu G, Zhang F, Li Y, Wu L. Novel systemic lupus erythematosus autoantigens identified by human protein microarray technology Biochem Biophys Res Commun. 2012 Feb 10;418(2):241-6.
6: Mi W, Li L, Su XD. 5,5′-Dithio-bis(2-nitrobenzoic acid) modification of cysteine improves the crystal quality of human chloride intracellular channel protein 2 Biochem Biophys Res Commun. 2008 Apr 18;368(4):919-22.
7: Witham S, Takano K, Schwartz C, Alexov E. A missense mutation in CLIC2 associated with intellectual disability is predicted by in silico modeling to affect protein stability and dynamics Proteins. 2011 Aug;79(8):2444-54.
8: Syahidatulamali CS, Wan Syamimee WG, Azwany YN, Wong KK, Che Maraina CH. Association of anti-CLIC2 and anti-HMGB1 autoantibodies with higher disease activity in systemic lupus erythematosus patients J Postgrad Med. 2017 Oct-Dec;63(4):257-261.
9: Ballout RA, El-Hattab AW, Schaaf CP, Cheung SW. Xq28 Duplication Syndrome, Int22h1/Int22h2 Mediated 2016 Mar 10 [updated 2021 Feb 25]. In: Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews(®) [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022.
10: Heiss NS, Poustka A. Genomic structure of a novel chloride channel gene, CLIC2, in Xq28 Genomics. 1997 Oct 1;45(1):224-8.

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Additional information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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