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Histidine Buffer (0.2 M, pH 7.0)

Original price was: $1,395.00.Current price is: $695.00.

Catalog Number: B2017977 (100 mL)
Histidine buffer (0.2 M, pH 7.0) is a solution containing the amino acid histidine. This buffer solution is commonly used in biochemical and biological experiments to maintain a stable pH environment. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2017977 Category: Tag:

Product Description

5/5 - (1 vote)

Histidine Buffer (0.2 M, pH 7.0)
Catalog number: B2017977
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 mL
Molecular Weight or Concentration: 0.2 M
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: 2-8℃
Keywords: N/A
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Holeček M. Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement Nutrients. 2020 Mar 22;12(3):848.
2: Doyle Drbohlav LM, Sharma AN, Gopalrathnam G, Huang L, Bradley S. A Mechanistic Understanding of Polysorbate 80 Oxidation in Histidine and Citrate Buffer Systems-Part 2 PDA J Pharm Sci Technol. 2019 Jul-Aug;73(4):320-330.
3: Berenbrink M. Evolution of vertebrate haemoglobins: Histidine side chains, specific buffer value and Bohr effect Respir Physiol Neurobiol. 2006 Nov;154(1-2):165-84.
4: Zhang Y, Schöneich C. Near UV light photo-degradation of histidine buffer: Mechanisms and role of Fe(III) Eur J Pharm Biopharm. 2023 Sep;190:231-241.
5: Lei M, Quan C, Wang YJ, Kao YH, Schöneich C. Light-Induced Covalent Buffer Adducts to Histidine in a Model Protein Pharm Res. 2018 Feb 20;35(3):67.
6: Kolhe P, Amend E, Singh SK. Impact of freezing on pH of buffered solutions and consequences for monoclonal antibody aggregation Biotechnol Prog. 2010 May-Jun;26(3):727-33.
7: Brovč EV, Mravljak J, Šink R, Pajk S. Degradation of polysorbates 20 and 80 catalysed by histidine chloride buffer Eur J Pharm Biopharm. 2020 Sep;154:236-245.
8: Zhang Y, Ballesteros ME, Schöneich C. Photo-induced site-specific oxidative fragmentation of IgG1 mediated by iron(III)-containing histidine buffer: Mechanistic studies and excipient effects Eur J Pharm Biopharm. 2023 Sep;190:121-130.
9: Zhang Y, Schöneich C. Visible Light Induces Site-Specific Oxidative Heavy Chain Fragmentation of a Monoclonal Antibody (IgG1) Mediated by an Iron(III)-Containing Histidine Buffer Mol Pharm. 2023 Jan 2;20(1):650-662.
10: Saurabh S, Kalonia C, Li Z, Hollowell P, Waigh T, Li P, Webster J, Seddon JM, Lu JR, Bresme F. Understanding the Stabilizing Effect of Histidine on mAb Aggregation: A Molecular Dynamics Study Mol Pharm. 2022 Sep 5;19(9):3288-3303.

Products Related to Histidine Buffer (0.2 M, pH 7.0) can be found at Chemicals

Additional Information

Weight 5.5 oz
Dimensions 5 × 3 × 3 in
5/5 - (1 vote)

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