High HAMA Serum and Plasma Matched Set

Product Description

High HAMA Serum and Plasma Matched Set

About HAMA

Immunoassays rely heavily on mouse antibodies for the detection of various analytes. The accuracy of these assays can, however, suffer when samples contain human anti-mouse antibodies (HAMA). Indeed, HAMA are often associated with inaccurate results because they can bind to both capture and detection antibodies and can generate non-specific signals. This so-called HAMA effect is major interference issue. Assessing the tolerance of an immunoassay to HAMA and mitigating it is very important important during research and development.

Products Related to High HAMA Serum and Plasma Matched Set: High HAMA Serum

References:
1: Mukherjee S, Ayanambakkam A, Ibrahimi S, Schmidt S, Charkrabarty JH, Khawandanah M. Ibritumomab tiuxetan (Zevalin) and elevated serum human anti-murine antibody (HAMA) Hematol Oncol Stem Cell Ther. 2018 Sep;11(3):187-188.
2: Klee GG. Human anti-mouse antibodies Arch Pathol Lab Med. 2000 Jun;124(6):921-3.
3: Wang G, An Y, Zhang X, Ding P, Bi H, Zhao Z. Chondrocyte Spheroids Laden in GelMA/HAMA Hybrid Hydrogel for Tissue-Engineered Cartilage with Enhanced Proliferation, Better Phenotype Maintenance, and Natural Morphological Structure Gels. 2021 Dec 2;7(4):247.
4: Mouser VH, Abbadessa A, Levato R, Hennink WE, Vermonden T, Gawlitta D, Malda J. Development of a thermosensitive HAMA-containing bio-ink for the fabrication of composite cartilage repair constructs Biofabrication. 2017 Mar 23;9(1):015026.
5: Maier W, Buller R, Philipp M, Heuser I. The Hamilton Anxiety Scale: reliability, validity and sensitivity to change in anxiety and depressive disorders J Affect Disord. 1988 Jan-Feb;14(1):61-8.
6: Imasaka KI, Tomita Y. Reply Ann Thorac Surg. 2018 Oct;106(4):1264-1265.
7: Imasaka KI, Tomita Y. Reply Ann Thorac Surg. 2018 Oct;106(4):1258-1259.
8: Xia C, Chen P, Mei S, Ning L, Lei C, Wang J, Zhang J, Ma J, Fan S. Photo-crosslinked HAMA hydrogel with cordycepin encapsulated chitosan microspheres for osteoarthritis treatment Oncotarget. 2017 Jan 10;8(2):2835-2849.
9: Kasper S, Gastpar M, Müller WE, Volz HP, Möller HJ, Schläfke S, Dienel A. Lavender oil preparation Silexan is effective in generalized anxiety disorder–a randomized, double-blind comparison to placebo and paroxetine Int J Neuropsychopharmacol. 2014 Jun;17(6):859-69.
10: Matza LS, Morlock R, Sexton C, Malley K, Feltner D. Identifying HAM-A cutoffs for mild, moderate, and severe generalized anxiety disorder Int J Methods Psychiatr Res. 2010 Dec;19(4):223-32.