Heptakis(2,3-di-O-methyl-6-deoxy-6-amino)-beta-cyclodextrin heptahydrochloride

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Heptakis(2,3-di-O-methyl-6-deoxy-6-amino)-beta-cyclodextrin heptahydrochloride

Original price was: $1,795.00.Current price is: $895.00.

Catalog Number: B2027382 (100 mg)
Heptakis(2,3-di-O-methyl-6-deoxy-6-amino)-beta-cyclodextrin heptahydrochloride is a chemically modified, cationic derivative of beta-cyclodextrin featuring per-functionalized methyl groups at the 2- and 3-positions and amino groups at the 6-positions. The methylation significantly enhances aqueous solubility while preserving the hydrophobic cavity for encapsulation of lipophilic host molecules. The primary amino groups, present as hydrochloride salts, impart a strong positive charge at physiological pH, making it useful for gene transfection and host-guest supramolecular chemistry. Custom bulk amounts of this product are available upon request.

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Product Description

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Heptakis(2,3-di-O-methyl-6-deoxy-6-amino)-beta-cyclodextrin heptahydrochloride
Catalog number: B2027382
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 mg
Molecular Weight or Concentration: 1579.7
Supplied as: Chemicals
Storage: 2-8 ËšC
Keywords: Heptakis(6-amino-6-deoxy-2,3-di-O-methyl)-beta-cyclodextrin heptahydrochloride, Per-6-amino-6-deoxy-2,3-di-O-methyl-beta-cyclodextrin heptahydrochloride

References:
1. Ashton, P. R., Ellwood, P., Staton, I., & Stoddart, J. F. (1991). Synthesis and characterization of per-functionalized beta-cyclodextrins. Journal of Organic Chemistry, 56(26), 7274-7280.
2. Khan, A. R., Forgo, P., & D’Souza, V. T. (1998). Selective modification of cyclodextrins. Chemical Reviews, 98(5), 1977-1996.
3. Tang, W., & Ng, S. C. (2008). Substituted beta-cyclodextrins as chiral selectors in capillary electrophoresis. Journal of Chromatography A, 1204(1), 3-15.
4. Szente, L., & Szejtli, J. (2004). Highly soluble cyclodextrin derivatives: chemistry, properties, and trends in development. Advanced Drug Delivery Reviews, 56(9), 1229-1249.
5. Croft, A. P., & Bartsch, R. A. (1983). Synthesis of chemically modified cyclodextrins. Tetrahedron, 39(9), 1417-1474.
6. Wenz, G., Han, B. H., & Müller, A. (2006). Cyclodextrin inclusion compounds: synthesis and applications. Chemical Reviews, 106(3), 782-817.
7. Szejtli, J. (1998). Introduction and general overview of cyclodextrin chemistry. Chemical Reviews, 98(5), 1743-1754.
8. Loftsson, T., & Duchêne, D. (2007). Cyclodextrins and their pharmaceutical applications. International Journal of Pharmaceutics, 329(1-2), 1-11.
9. Davis, M. E., & Brewster, M. E. (2004). Cyclodextrin-based pharmaceutics: past, present and future. Nature Reviews Drug Discovery, 3(12), 1023-1035.
10. Jansook, P., Ogawa, N., & Loftsson, T. (2018). Cyclodextrins: structure, physicochemical properties and pharmaceutical applications. International Journal of Pharmaceutics, 535(1-2), 272-284.
Heptakis(2,3-di-O-methyl-6-deoxy-6-amino)-beta-cyclodextrin heptahydrochloride

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Additional Information

Weight 0.15 oz
Dimensions 2 × 0.5 × 0.5 in
5/5 - (1 vote)

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