GSK3 Substrate


Catalog Number: B2011106 (1 mg)
GSK3 Substrate is a high quality substrate for both alpha and beta isoforms of GSK3. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2011106 Categories: ,


GSK3 Substrate
Catalog number: B2011106
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 2630 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: GSK3 Substrate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Beurel E, Grieco SF, Jope RS. Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases Pharmacol Ther. 2015 Apr;148:114-31.
2: Hermida MA, Dinesh Kumar J, Leslie NR. GSK3 and its interactions with the PI3K/AKT/mTOR signalling network Adv Biol Regul. 2017 Aug;65:5-15.
3: Wadhwa P, Jain P, Jadhav HR. Glycogen Synthase Kinase 3 (GSK3): Its Role and Inhibitors Curr Top Med Chem. 2020;20(17):1522-1534.
4: Duda P, Akula SM, Abrams SL, Steelman LS, Martelli AM, Cocco L, Ratti S, Candido S, Libra M, Montalto G, Cervello M, Gizak A, Rakus D, McCubrey JA. Targeting GSK3 and Associated Signaling Pathways Involved in Cancer Cells. 2020 Apr 30;9(5):1110.
5: Kazi A, Xiang S, Yang H, Delitto D, Trevino J, Jiang RHY, Ayaz M, Lawrence HR, Kennedy P, Sebti SM. GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors Nat Commun. 2018 Dec 4;9(1):5154.
6: Panagi I, Jennings E, Zeng J, Günster RA, Stones CD, Mak H, Jin E, Stapels DAC, Subari NZ, Pham THM, Brewer SM, Ong SYQ, Monack DM, Helaine S, Thurston TLM. Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization Cell Host Microbe. 2020 Jan 8;27(1):41-53.e6.
7: Li J, Zhou H, Zhang Y, Li Z, Yang Y, Guo Y. The GSK3-like Kinase BIN2 Is a Molecular Switch between the Salt Stress Response and Growth Recovery in Arabidopsis thaliana Dev Cell. 2020 Nov 9;55(3):367-380.e6.
8: Robertson H, Hayes JD, Sutherland C. A partnership with the proteasome; the destructive nature of GSK3 Biochem Pharmacol. 2018 Jan;147:77-92.
9: Mao J, Li W, Liu J, Li J. Versatile Physiological Functions of Plant GSK3-Like Kinases Genes (Basel). 2021 May 8;12(5):697.
10: Duan X, Norris DM, Humphrey SJ, Yang P, Cooke KC, Bultitude WP, Parker BL, Conway OJ, Burchfield JG, Krycer JR, Brodsky FM, James DE, Fazakerley DJ. Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate Biochem J. 2022 Jun 17;479(11):1237-1256.

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