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GnGn-bi-Asn-PABA (Highly Pure)

$950.00

Catalog Number: MDP0881 (0.1 mg)
GnGn-bi-Asn-PABA is a highly pure semisynthetic compound. This product has been used as substrate for GDP-L-Fuc: N-Acetyl-beta-D-Glucosaminide alpha1-6Fucosyltransferase. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: MDP0881 Category:

Description

GnGn-bi-Asn-PABA
Catalog number: MDP0881
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 0.1 mg
Molecular Weight or Concentration: 1578.5 g/mol
Supplied as: Powder
Applications: substrate for GDP-L-Fuc: N-Acetyl-beta-D-Glucosaminide alpha1-6Fucosyltransferase
Storage: -20°C
Keywords: O-beta-2-Acetamido-2-deoxy-D-glucopyranosyl-(1?2)-O-alpha-D-mannopyranosyl-(1?3)-[O-beta-2-acetamido-2-deoxy-D-glucopyranosyl-(1?2)-O-alpha-D-mannopyranosyl-(1?6)]-O-beta-D-mannopyranosyl-(1?4)-O-beta-2-acetamido-2-deoxy-D-glucopyranosyl-(1?4)-N-beta-2-acetamido-2-deoxy-D-glucopyranosyl-(1?4)-L-asparagine 4-(2-pyridylamino)butylamide
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
Indication for Use:This product is for Research Use Only. This product is NOT for human or animal use.

References:
1: Bastian K, Scott E, Elliott DJ, Munkley J. FUT8
Alpha-(1,6)-Fucosyltransferase in Cancer. Int J Mol Sci. 2021 Jan 5;22(1):455.

2: Tada K, Ohta M, Hidano S, Watanabe K, Hirashita T, Oshima Y, Fujnaga A,
Nakanuma H, Masuda T, Endo Y, Takeuchi Y, Iwashita Y, Kobayashi T, Inomata M.
Fucosyltransferase 8 plays a crucial role in the invasion and metastasis of
pancreatic ductal adenocarcinoma. Surg Today. 2020 Jul;50(7):767-777.

3: Merino P, Tejero T, Delso I, Hurtado-Guerrero R, Gómez-SanJuan A, Sádaba D.
Recent progress on fucosyltransferase inhibitors. Mini Rev Med Chem. 2012
Dec;12(14):1455-64.

4: Tu Z, Lin YN, Lin CH. Development of fucosyltransferase and fucosidase
inhibitors. Chem Soc Rev. 2013 May 21;42(10):4459-75.

5: García-García A, Ceballos-Laita L, Serna S, Artschwager R, Reichardt NC,
Corzana F, Hurtado-Guerrero R. Structural basis for substrate specificity and
catalysis of α1,6-fucosyltransferase. Nat Commun. 2020 Feb 20;11(1):973.

6: Vodovar N, Schweisguth F. Functions of O-fucosyltransferase in Notch
trafficking and signaling: towards the end of a controversy? J Biol.
2008;7(2):7.

7: Strecker C, Baerenfaenger M, Miehe M, Spillner E, Meyer B. In Silico
Evaluation of the Binding Site of Fucosyltransferase 8 and First Attempts to
Synthesize an Inhibitor with Drug-Like Properties. Chembiochem. 2020 Jul
1;21(13):1923-1931.

8: Järvå MA, Dramicanin M, Lingford JP, Mao R, John A, Jarman KE, Grinter R,
Goddard-Borger ED. Structural basis of substrate recognition and catalysis by
fucosyltransferase 8. J Biol Chem. 2020 May 8;295(19):6677-6688.

9: Boruah BM, Kadirvelraj R, Liu L, Ramiah A, Li C, Zong G, Bosman GP, Yang JY,
Wang LX, Boons GJ, Wood ZA, Moremen KW. Characterizing human
α-1,6-fucosyltransferase (FUT8) substrate specificity and structural
similarities with related fucosyltransferases. J Biol Chem. 2020 Dec
11;295(50):17027-17045.
10: Tan Y, Zhang Y, Han Y, Liu H, Chen H, Ma F, Withers SG, Feng Y, Yang G.
Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-
throughput screening method. Sci Adv. 2019 Oct 9;5(10):eaaw8451.

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