Fluorescent Kallikrein Substrate

Product Description

Fluorescent Kallikrein Substrate
Catalog number: B2011313
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 612.7 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: Kallikrein Substrate, fluorescent Z-Phe-Arg-AMC
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Gruba N, Rachubik P, Piwkowska A, Lesner A. Analysis of urinary kallikrein-related peptidase 13 for monitoring bladder cancer Biomarkers. 2021 Dec;26(8):770-779.
2: Andrade D, Assis DM, Santos JA, Alves FM, Hirata IY, Araujo MS, Blaber SI, Blaber M, Juliano MA, Juliano L. Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates Biochimie. 2011 Oct;93(10):1701-9.
3: Cloutier SM, Chagas JR, Mach JP, Gygi CM, Leisinger HJ, Deperthes D. Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology Eur J Biochem. 2002 Jun;269(11):2747-54.
4: Lara-Marquez ML, Christiansen SC, Riedl MA, Herschbach J, Zuraw BL. Threshold-stimulated kallikrein activity distinguishes bradykinin- from histamine-mediated angioedema Clin Exp Allergy. 2018 Nov;48(11):1429-1438.
5: Oliva ML, Andrade SA, Batista IF, Sampaio MU, Juliano M, Fritz H, Auerswald EA, Sampaio CA. Human plasma kallikrein and tissue kallikrein binding to a substrate based on the reactive site of a factor Xa inhibitor isolated from Bauhinia ungulata seeds Immunopharmacology. 1999 Dec;45(1-3):145-9.
6: Angelo PF, Lima AR, Alves FM, Blaber SI, Scarisbrick IA, Blaber M, Juliano L, Juliano MA. Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects J Biol Chem. 2006 Feb 10;281(6):3116-26.
7: Andrade D, Assis DM, Lima AR, Oliveira JR, Araujo MS, Blaber SI, Blaber M, Juliano MA, Juliano L. Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate and glycosaminoglycans Arch Biochem Biophys. 2010 Jun 1;498(1):74-82.
8: Zhu YD, Peng J, Jiang LP, Zhu JJ. Fluorescent immunosensor based on CuS nanoparticles for sensitive detection of cancer biomarker Analyst. 2014 Feb 7;139(3):649-55.
9: Pimenta DC, Oliveira A, Juliano MA, Juliano L. Substrate specificity of human cathepsin D using internally quenched fluorescent peptides derived from reactive site loop of kallistatin Biochim Biophys Acta. 2001 Jan 12;1544(1-2):113-22.
10: Breger JC, Sapsford KE, Ganek J, Susumu K, Stewart MH, Medintz IL. Detecting kallikrein proteolytic activity with peptide-quantum dot nanosensors ACS Appl Mater Interfaces. 2014 Jul 23;6(14):11529-35.

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