ENPP1 Human Recombinant

Product Description

ENPP1 Human Recombinant
Catalog number: B2016912
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: 98.7 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: CD203a, Ectonucleotide Pyrophosphatase/Phosphodiesterase 1, Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1, Membrane Component Chromosome 6 Surface Marker 1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Jacobs IJ, Cheng Z, Ralph D, O’Brien K, Flaman L, Howe J, Thompson D, Uitto J, Li Q, Sabbagh Y. INZ-701, a recombinant ENPP1 enzyme, prevents ectopic calcification in an Abcc6(-/-) mouse model of pseudoxanthoma elasticum Exp Dermatol. 2022 Jul;31(7):1095-1101.
2: Ferreira CR, Kavanagh D, Oheim R, Zimmerman K, Stürznickel J, Li X, Stabach P, Rettig RL, Calderone L, MacKichan C, Wang A, Hutchinson HA, Nelson T, Tommasini SM, von Kroge S, Fiedler IA, Lester ER, Moeckel GW, Busse B, Schinke T, Carpenter TO, Levine MA, Horowitz MC, Braddock DT. Response of the ENPP1-Deficient Skeletal Phenotype to Oral Phosphate Supplementation and/or Enzyme Replacement Therapy: Comparative Studies in Humans and Mice J Bone Miner Res. 2021 May;36(5):942-955.
3: Gao MM, Su QN, Liang TZ, Ma JX, Liang TZ, Stoddart MJ, Richards RG, Zhou ZY, Zou NX. Transcriptional activation of ENPP1 by osterix in osteoblasts and osteocytes Eur Cell Mater. 2018 Jul 25;36:1-14.
4: Nitschke Y, Yan Y, Buers I, Kintziger K, Askew K, Rutsch F. ENPP1-Fc prevents neointima formation in generalized arterial calcification of infancy through the generation of AMP Exp Mol Med. 2018 Oct 29;50(10):1-12.
5: Ferreira CR, Ansh AJ, Nester C, O’Brien C, Stabach PR, Murtada SI, Lester ER, Khursigara G, Molloy L, Carpenter TO, Braddock DT. Musculoskeletal Comorbidities and Quality of Life in ENPP1-Deficient Adults and the Response of Enthesopathy to Enzyme Replacement Therapy in Murine Models J Bone Miner Res. 2022 Mar;37(3):494-504.
6: Palazzo L, Daniels CM, Nettleship JE, Rahman N, McPherson RL, Ong SE, Kato K, Nureki O, Leung AK, Ahel I. ENPP1 processes protein ADP-ribosylation in vitro FEBS J. 2016 Sep;283(18):3371-88.
7: Ito N, Prideaux M, Wijenayaka AR, Yang D, Ormsby RT, Bonewald LF, Atkins GJ. Sclerostin Directly Stimulates Osteocyte Synthesis of Fibroblast Growth Factor-23 Calcif Tissue Int. 2021 Jul;109(1):66-76.
8: Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Hydrolysis of 2’3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs Nat Chem Biol. 2014 Dec;10(12):1043-8.
9: Stabach PR, Zimmerman K, Adame A, Kavanagh D, Saeui CT, Agatemor C, Gray S, Cao W, De La Cruz EM, Yarema KJ, Braddock DT. Improving the Pharmacodynamics and In Vivo Activity of ENPP1-Fc Through Protein and Glycosylation Engineering Clin Transl Sci. 2021 Jan;14(1):362-372.
10: Wang H, Ye F, Zhou C, Cheng Q, Chen H. High expression of ENPP1 in high-grade serous ovarian carcinoma predicts poor prognosis and as a molecular therapy target PLoS One. 2021 Feb 26;16(2):e0245733.

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