DNA-PK Substrate (Highly Pure)

Product Description

DNA-PK Substrate (Highly Pure)
Catalog number: B2011307
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 2.5 mg
Molecular Weight or Concentration: 1759.1 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: DNA PK
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW. Chromothripsis drives the evolution of gene amplification in cancer Nature. 2021 Mar;591(7848):137-141.
2: Yue X, Bai C, Xie D, Ma T, Zhou PK. DNA-PKcs: A Multi-Faceted Player in DNA Damage Response Front Genet. 2020 Dec 23;11:607428.
3: Meek K. Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation Nucleic Acids Res. 2020 Sep 18;48(16):9098-9108.
4: Puustinen P, Keldsbo A, Corcelle-Termeau E, Ngoei K, Sønder SL, Farkas T, Kaae Andersen K, Oakhill JS, Jäättelä M. DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy Autophagy. 2020 Oct;16(10):1871-1888.
5: Fan XJ, Wang YL, Zhao WW, Bai SM, Ma Y, Yin XK, Feng LL, Feng WX, Wang YN, Liu Q, Hung MC, Wan XB. NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation Am J Cancer Res. 2021 Jun 15;11(6):2838-2852. eCollection 2021.
6: Bravo JPK, Liu MS, Hibshman GN, Dangerfield TL, Jung K, McCool RS, Johnson KA, Taylor DW. Structural basis for mismatch surveillance by CRISPR-Cas9 Nature. 2022 Mar;603(7900):343-347.
7: Solier S, Kohn KW, Scroggins B, Xu W, Trepel J, Neckers L, Pommier Y. Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12866-72.
8: Justice JL, Kennedy MA, Hutton JE, Liu D, Song B, Phelan B, Cristea IM. Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity Sci Adv. 2021 Jun 18;7(25):eabg6680.
9: Hall-Jackson CA, Cross DA, Morrice N, Smythe C. ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK Oncogene. 1999 Nov 18;18(48):6707-13.
10: Djuzenova CS, Fischer T, Katzer A, Sisario D, Korsa T, Steussloff G, Sukhorukov VL, Flentje M. Opposite effects of the triple target (DNA-PK/PI3K/mTOR) inhibitor PI-103 on the radiation sensitivity of glioblastoma cell lines proficient and deficient in DNA-PKcs BMC Cancer. 2021 Nov 11;21(1):1201.

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