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dATP (2′-Deoxyadenosine 5′-triphosphate 100 mM )

$295.00

Catalog Number: B2010541 (250 uL)
dATP (2′-Deoxyadenosine 5′-triphosphate 100 mM ) is a highly pure PCR-grade solution of the dATP nucleotide. This product has been used in DNA synthesis reactions, DNA sequencing and molecular cloning . It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2010541 Categories: ,

Description

dATP (2′-Deoxyadenosine 5′-triphosphate 100 mM )
Catalog number: B2010541
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 250 uL
Molecular Weight or Concentration: 100 mM
Supplied as: Solution
Applications: DNA synthesis reactions, DNA sequencing and molecular cloning
Storage: −20°C
Keywords: 2′-Deoxyadenosine 5′-triphosphate sodium salt solution, dATP
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Schreier VN, Loehr MO, Deng T, Lattmann E, Hajnal A, Neuhauss SCF, Luedtke
NW. Fluorescent dATP for DNA Synthesis In Vivo. ACS Chem Biol. 2020 Nov
20;15(11):2996-3003.

2: Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X.
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates
an apoptotic protease cascade. Cell. 1997 Nov 14;91(4):479-89.

3: Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in
cell-free extracts: requirement for dATP and cytochrome c. Cell. 1996 Jul
12;86(1):147-57.

4: McCabe KJ, Aboelkassem Y, Teitgen AE, Huber GA, McCammon JA, Regnier M,
McCulloch AD. Predicting the effects of dATP on cardiac contraction using
multiscale modeling of the sarcomere. Arch Biochem Biophys. 2020 Nov
30;695:108582.

5: Scaletti ER, Vallin KS, Bräutigam L, Sarno A, Warpman Berglund U, Helleday T,
Stenmark P, Jemth AS. MutT homologue 1 (MTH1) removes N6-methyl-dATP from the
dNTP pool. J Biol Chem. 2020 Apr 10;295(15):4761-4772.

6: Nayak S, Bryant FR. Kinetics of the ATP and dATP-mediated formation of a
functionally-active RecA-ssDNA complex. Biochem Biophys Res Commun. 2015 Aug
7;463(4):1257-61.

7: Parker MJ, Maggiolo AO, Thomas WC, Kim A, Meisburger SP, Ando N, Boal AK,
Stubbe J. An endogenous dAMP ligand in Bacillus subtilis class Ib RNR
promotes assembly of a noncanonical dimer for regulation by dATP. Proc Natl Acad
Sci U S A. 2018 May 15;115(20):E4594-E4603.

8: Matyašovský J, Perlíková P, Malnuit V, Pohl R, Hocek M. 2-Substituted d ATP
Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA
Modified in the Minor Groove. Angew Chem Int Ed Engl. 2016 Dec
19;55(51):15856-15859.

9: Lundy SD, Murphy SA, Dupras SK, Dai J, Murry CE, Laflamme MA, Regnier M.
Cell-based delivery of d ATP via gap junctions enhances cardiac contractility. J
Mol Cell Cardiol. 2014 Jul;72:350-9.

10: Xi C, Wu J. dATP/ATP, a multifunctional nucleotide, stimulates bacterial
cell lysis, extracellular DNA release and biofilm development. PLoS One. 2010
Oct 14;5(10):e13355.

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