D-Glucaro-δ-Lactam (Highly Pure)

Description

D-Glucaro-δ-Lactam
Catalog number: MDP0890
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 191.14 g/mol
Supplied as: Powder
Applications: glycosidase Inhibitor
Storage: -20°C
Keywords: (2S,3R,4S,5R)-3,4,5-Trihydroxy-6-Oxo-2-Piperidinecarboxylic Acid, D-Glucaro-d-Lactam
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
Indication for Use:This product is for Research Use Only. This product is NOT for human or animal use.

References:
1: Tsuruoka T, Azetaka M, Iizuka Y, Saito K, Inouye S, Hosokawa M, Kobayashi H.
Inhibition of tumor cell haptotaxis by sodium D-glucaro-delta-lactam (ND2001).
Jpn J Cancer Res. 1995 Nov;86(11):1080-5.

2: Nishimura Y. gem-Diamine 1-N-iminosugars and related iminosugars, candidate
of therapeutic agents for tumor metastasis. Curr Top Med Chem. 2003;3(5):575-91.

3: Marre R, Müller W, Sack K. Animal studies on the reduction of aminoglycoside-
induced nephrotoxicity by D-glucaro-1,5-lactam. Infection. 1983 May-
Jun;11(3):155-60.

4: Tsuruoka T, Fukuyasu H, Ishii M, Usui T, Shibahara S, Inouye S. Inhibition of
mouse tumor metastasis with nojirimycin-related compounds. J Antibiot (Tokyo).
1996 Feb;49(2):155-61.

5: Nizato T, Koeda T, Tsuruoka T, Inouye S, Niida T. Protective effect of
D-glucaro-delta-lactam against amino-glycoside-induced nephrotoxicity in rats. J
Antibiot (Tokyo). 1976 Aug;29(8):833-40.

6: Fujii Y, Iwasa H, Hirai J, Takahama Y, Hasumi K, Eriguchi M. Inhibition of
liver metastases and tumor cell invasion in spontaneous liver metastasis model
(LMFS) by sodium D-glucaro-delta-lactam (ND2001). Biomed Pharmacother. 2000
Mar;54(2):85-92.

7: Tsuruoka T, Fukuyasu H, Azetaka M, Iizuka Y, Inouye S, Hosokawa M, Kobayashi
H. Inhibition of pulmonary metastases and tumor cell invasion in experimental
tumors by sodium D-glucaro-delta-lactam (ND2001). Jpn J Cancer Res. 1995
Jan;86(1):41-7.

8: Kuramitsu Y, Hamada J, Tsuruoka T, Morikawa K, Kobayashi H, Hosokawa M. A new
anti-metastatic drug, ND-2001, inhibits lung metastases in rat hepatoma cells by
suppressing haptotaxis of tumor cells toward laminin. Anticancer Drugs. 1998
Jan;9(1):88-92.

9: Marre R, Ost C, Sack K. Tierexperimentelle Studien mit Ribostamycin [Animal
studies on ribostamycin (author’s transl)]. Immun Infekt. 1981 Apr;9(2):66-71.
German.
10: Kuramitsu Y, Hamada J, Tsuruoka T, Morikawa K, Naito S, Kobayashi H,
Hosokawa M. ND-2001 suppresses lung metastasis of human renal cancer cells in
athymic mice. Anticancer Drugs. 1998 Sep;9(8):739-41.

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