Chromogenic Substrate for Thrombin

Product Description

Chromogenic Substrate for Thrombin
Catalog number: B2014469
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 625.6
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Chromogenic Substrate for Thrombin
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Meddahi S, Bara L, Fessi H, Samama MM. Standard measurement of clot-bound thrombin by using a chromogenic substrate for thrombin Thromb Res. 2004;114(1):51-6.
2: Zhao Q, Wang X. An aptamer-capture based chromogenic assay for thrombin Biosens Bioelectron. 2012 Apr 15;34(1):232-7.
3: Yamaguchi T, Shinozawa K, Nagatoishi S, Mitsuhashi A, Bingo M, Inaba H, Amano K, Tsumoto K, Kinai E. In vitro validation of chromogenic substrate assay for evaluation of surrogate FVIII-activity of emicizumab Thromb Res. 2023 Feb;222:131-139.
4: Arian D, Harenberg J, Krämer R. A Chromogenic and Fluorogenic Peptide Substrate for the Highly Sensitive Detection of Proteases in Biological Matrices J Med Chem. 2016 Aug 25;59(16):7576-83.
5: Aiyappa PA. Chromogenic substrate spectrophotometric assays for the measurement of clotting function Ann N Y Acad Sci. 1981;370:812-21.
6: Wang C, Zhao Q. A competitive thrombin-linked aptamer assay for small molecule: aflatoxin B(1) Anal Bioanal Chem. 2019 Oct;411(25):6637-6644.
7: Jaffer IH, Chan N, Roberts R, Fredenburgh JC, Eikelboom JW, Weitz JI. Comparison of the ecarin chromogenic assay and diluted thrombin time for quantification of dabigatran concentrations J Thromb Haemost. 2017 Dec;15(12):2377-2387.
8: Hafner G, Roser M, Nauck M. Methods for the monitoring of direct thrombin inhibitors Semin Thromb Hemost. 2002 Oct;28(5):425-30.
9: Blombäck M, Blombäck B, Olsson P, Svendsen L. The assay of antithrombin using a synthetic chromogenic substrate for thrombin Thromb Res. 1974 Nov;5(5):621-32.
10: Rosén S, Andersson M, Blombäck M, Hägglund U, Larrieu MJ, Wolf M, Boyer C, Rothschild C, Nilsson IM, Sjörin E, et al. Clinical application of a chromogenic substrate method for determination of factor VIII activity Thromb Haemost. 1985 Dec 17;54(4):818-23.

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