CDK1 Substrate (Highly Pure)

Product Description

CDK1 Substrate (Highly Pure)
Catalog number: B2011298
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 2.5 mg
Molecular Weight or Concentration: 1190.5 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: CDC2, CDK1 substrate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Michowski W, Chick JM, Chu C, Kolodziejczyk A, Wang Y, Suski JM, Abraham B, Anders L, Day D, Dunkl LM, Li Cheong Man M, Zhang T, Laphanuwat P, Bacon NA, Liu L, Fassl A, Sharma S, Otto T, Jecrois E, Han R, Sweeney KE, Marro S, Wernig M, Geng Y, Moses A, Li C, Gygi SP, Young RA, Sicinski P. Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells Mol Cell. 2020 May 7;78(3):459-476.e13.
2: Lu X, Pang Y, Cao H, Liu X, Tu L, Shen Y, Jia X, Lee JC, Wang Y. Integrated Screens Identify CDK1 as a Therapeutic Target in Advanced Gastrointestinal Stromal Tumors Cancer Res. 2021 May 1;81(9):2481-2494.
3: Yu J, Raia P, Ghent CM, Raisch T, Sadian Y, Cavadini S, Sabale PM, Barford D, Raunser S, Morgan DO, Boland A. Structural basis of human separase regulation by securin and CDK1-cyclin B1 Nature. 2021 Aug;596(7870):138-142.
4: Kawashima AT, Wong C, Lordén G, King CC, Lara-Gonzalez P, Desai A, Gingras AC, Newton AC. The PHLPP1 N-Terminal Extension is a Mitotic Cdk1 Substrate and Controls an Interactome Switch Mol Cell Biol. 2021 Jan 4;41(3):e00333-20.
5: Yamano H. APC/C: current understanding and future perspectives F1000Res. 2019 May 23;8:F1000 Faculty Rev-725.
6: Kõivomägi M, Swaffer MP, Turner JJ, Marinov G, Skotheim JM. G(1) cyclin-Cdk promotes cell cycle entry through localized phosphorylation of RNA polymerase II Science. 2021 Oct 15;374(6565):347-351.
7: Watanabe R, Hara M, Ariyoshi M, Fukagawa T. CENP-C Phosphorylation by CDK1 in vitro Bio Protoc. 2021 Jan 5;11(1):e3879.
8: Mangione MC, Chen JS, Gould KL. Cdk1 phosphorylation of fission yeast paxillin inhibits its cytokinetic ring localization Mol Biol Cell. 2021 Aug 15;32(17):1534-1544.
9: Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan DO, Loog M. Dynamics of Cdk1 substrate specificity during the cell cycle Mol Cell. 2011 Jun 10;42(5):610-23.
10: Kõivomägi M, Loog M. Cdk1: a kinase with changing substrate specificity Cell Cycle. 2011 Nov 1;10(21):3625-6.

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