Caspase 3 Apopain Substrate

Product Description

Caspase 3 Apopain Substrate
Catalog number: B2012959
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 2.5 mg
Molecular Weight or Concentration: N/A
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: N-acetyl-asp-glu-val-asp-7-amino-4-trifluoromethyl coumarin, Ac-DEVD-7-AFC
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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2: Choudhary GS, Al-Harbi S, Almasan A. Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis Methods Mol Biol. 2015;1219:1-9.
3: Araya LE, Soni IV, Hardy JA, Julien O. Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling ACS Chem Biol. 2021 Nov 19;16(11):2280-2296.
4: Xu WF, Zhang Q, Ding CJ, Sun HY, Che Y, Huang H, Wang Y, Wu JW, Hao HP, Cao LJ. Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure Acta Pharmacol Sin. 2021 Jan;42(1):68-76.
5: Beroske L, Van den Wyngaert T, Stroobants S, Van der Veken P, Elvas F. Molecular Imaging of Apoptosis: The Case of Caspase-3 Radiotracers Int J Mol Sci. 2021 Apr 11;22(8):3948.
6: Datta D, McClendon CL, Jacobson MP, Wells JA. Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3 J Biol Chem. 2013 Apr 5;288(14):9971-9981.
7: McKenzie BA, Fernandes JP, Doan MAL, Schmitt LM, Branton WG, Power C. Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis J Neuroinflammation. 2020 Aug 29;17(1):253.
8: Man N, Tan Y, Sun XJ, Liu F, Cheng G, Greenblatt SM, Martinez C, Karl DL, Ando K, Sun M, Hou D, Chen B, Xu M, Yang FC, Chen Z, Chen S, Nimer SD, Wang L. Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner Blood. 2017 May 18;129(20):2782-2792.
9: Yao L, Swartz P, Hamilton PT, Clark AC. Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3 Biosci Rep. 2021 Jan 29;41(1):BSR20203495.
10: Ruan J, Gao S, Yang J, Li H, Huang H, Zheng X. WT1 protein is cleaved by caspase-3 in apoptotic leukemic cells Leuk Lymphoma. 2018 Jan;59(1):162-170.

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