Bis(6-deoxy-6-chloro)-hexakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin

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Bis(6-deoxy-6-chloro)-hexakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin
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Bis(6-deoxy-6-chloro)-hexakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin

Original price was: $1,795.00.Current price is: $895.00.

Catalog Number: B2027394 (100 mg)
Bis(6-deoxy-6-chloro)-hexakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin is a selectively modified gamma-cyclodextrin derivative featuring two chloro substitutions and six carboxyethylthio functional groups at the primary C6 positions. The introduction of carboxyethylthio moieties imparts hydrophilic carboxylic acid functionality to the macrocycle, significantly altering its aqueous solubility and host-guest binding capability. This specialized cyclic oligosaccharide serves as an analytical standard and reagent for host-guest encapsulation research, supramolecular chemistry, and molecular delivery applications. Custom bulk amounts of this product are available upon request.

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Product Description

5/5 - (1 vote)

Bis(6-deoxy-6-chloro)-hexakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin
Catalog number: B2027394
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 mg
Molecular Weight or Concentration: NA
Supplied as: Chemicals
Storage: −80°C
Keywords: Sugammadex dichloro impurity, Dichlorosugammadex, Sugammadex impurity A

References:
1. Loftsson, T., & Duchêne, D. (2007). Cyclodextrins and their pharmaceutical applications. International Journal of Pharmaceutics, 329(1-2), 1-11.
2. Szejtli, J. (1998). Introduction and general overview of cyclodextrin chemistry. Chemical Reviews, 98(5), 1743-1754.
3. Davis, M. E., & Brewster, M. E. (2004). Cyclodextrin-based pharmaceutics: past, present and future. Nature Reviews Drug Discovery, 3(12), 1023-1035.
4. Stella, V. J., & He, Q. (2008). Cyclodextrins. Toxicologic Pathology, 36(1), 30-42.
5. Vyas, A., Saraf, S., & Saraf, S. (2008). Cyclodextrin based novel drug delivery systems. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 62(1), 23-42.
6. Del Valle, E. M. (2004). Cyclodextrins and their uses: a review. Process Biochemistry, 39(9), 1033-1046.
7. Szente, L., & Szejtli, J. (2004). Highly soluble cyclodextrin derivatives: chemistry, properties, and trends in development. Advanced Drug Delivery Reviews, 56(9), 1229-1249.
8. Kurkov, S. V., & Loftsson, T. (2013). Cyclodextrins. International Journal of Pharmaceutics, 453(1), 167-180.
9. Jansook, P., Ogawa, N., & Loftsson, T. (2018). Cyclodextrins: structure, physicochemical properties and pharmaceutical applications. International Journal of Pharmaceutics, 535(1-2), 272-284.
10. Welliver, M. (2006). Sugammadex: a selective relaxant binding agent. AANA Journal, 74(5), 357-363.
Bis(6-deoxy-6-chloro)-hexakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin

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Additional Information

Weight 0.15 oz
Dimensions 2 × 0.5 × 0.5 in
5/5 - (1 vote)

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