Bis(4-nitrophenyl) Phosphate


Catalog Number: B2012283 (100 mg)
Bis(4-nitrophenyl) Phosphate is a high quality Phosphodiesterase Substrate. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Bis(4-nitrophenyl) Phosphate
Catalog number: B2012283
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 mg
Molecular Weight or Concentration: 340.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20C
Keywords: Phosphoric Acid Bis(4-nitrophenyl) Ester
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Starynowicz P, Lis T. Charge-density distribution in sodium bis(4-nitrophenyl)phosphate Acta Crystallogr B Struct Sci Cryst Eng Mater. 2014 Aug;70(Pt 4):723-31.
2: Yi XY, Lam TC, Williams ID, Leung WH. Hydrolysis of bis(p-nitrophenyl)phosphate by tetravalent metal complexes with Klaui’s oxygen tripodal ligand Inorg Chem. 2010 Mar 1;49(5):2232-8.
3: Cacan R, Hoflack B, Verbert A. Effect of bis-(p-nitrophenyl) phosphate on the biosynthesis and the utilization of lipid-intermediates Biochem J. 1982 Sep 1;205(3):603-9.
4: Guette F, Cacan R, Montreuil J, Verbert A. Inhibition of glycosyltransferases by bis-(p-nitrophenyl)phosphate: general effect and relation to their membrane integration Biochimie. 1983 Oct;65(10):563-7.
5: Hisamatsu Y, Miyazawa Y, Yoneda K, Miyauchi M, Zulkefeli M, Aoki S. Supramolecular Complexes Formed by the Self-assembly of Hydrophobic Bis(Zn(2+)-cyclen) Complexes, Copper, and Di- or Triimide Units for the Hydrolysis of Phosphate Mono- and Diesters in Two-Phase Solvent Systems (Cyclen=1,4,7,10-Tetraazacyclododecane) Chem Pharm Bull (Tokyo). 2016;64(5):451-64.
6: Brandt E, Heymann E. Enzymatic hydrolysis of bis-(4-nitrophenyl)phosphate and bis-(4-cyanophenyl)phosphate by rat tissues Biochem Pharmacol. 1978 Mar 1;27(5):773-7.
7: Hawley DM, Hodes MZ, Crisp M, Ellis G, Karn RC, Hodes ME. Characterization of phosphohydrolase activity in bovine spleen extracts: identification of a bis(p-nitrophenyl)phosphate-hydrolyzing activity (phosphodiesterase IV) which also acts on adenosine triphosphate Anal Biochem. 1985 Dec;151(2):375-80.
8: White KN, Eggermont J, Hope DB. Effect of the carboxylesterase inhibitor bis-(4-nitrophenyl)phosphate in vivo on aspirin hydrolase and carboxylesterase activities at first-pass sites of metabolism in the guinea pig Biochem Pharmacol. 1987 Aug 15;36(16):2687-8.
9: Tsugoshi Y, Watanabe Y, Tanikawa Y, Inoue C, Sugihara K, Kojima H, Kitamura S. Inhibitory effects of organophosphate esters on carboxylesterase activity of rat liver microsomes Chem Biol Interact. 2020 Aug 25;327:109148.
10: Parli CJ, Evenson E, Potts BD, Beedle E, Lawson R, Robertson DW, Leander JD. Metabolism of the prodrug DEGA (N-(2,6-dimethylphenyl)-4-[[(diethylamino)acetyl]amino]benzamide) to the potent anticonvulsant LY201116 in mice. Effect of bis-(p-nitrophenyl)phosphate Drug Metab Dispos. 1988 Sep-Oct;16(5):707-11.

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