Benzyloxycarbonyl-L-leucyl-L-leucinal

$199.00

Catalog number: MDP0226
Name: Benzyloxycarbonyl-L-leucyl-L-leucinal
Other name(s): Z-Leu-Leu-H (aldehyde)
Molecular Formula: C20H30N2O4
Molecular Mass: 362.46
CAS #: 134865-05-7
Storage Temperature: -20 C
Amount needed (x 1 mg):

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SKU: MDP0226 Category:

Description

Benzyloxycarbonyl-L-leucyl-L-leucinal

Price per 1 mg: $199
Catalog number: MDP0226
Name: Benzyloxycarbonyl-L-leucyl-L-leucinal
Other name(s): Z-Leu-Leu-H (aldehyde)
Molecular Formula: C20H30N2O4
Molecular Mass: 362.46
CAS #: 134865-05-7
Storage Temperature: -20 C
Ships from: California

Structure:


Indication for Use:
This product if for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use.

Safety:
User must review the Material Safety Data Sheet (MSDS) provided with this product. In addition, this product should not be ingested, inhaled, swallowed or put in contact with eyes, skin or clothes.

Applications: Inhibitor of Calpain

References

1: Ito H, Watanabe M, Kim YT, Takahashi K. Inhibition of rat liver cathepsins B
and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-leucinal and its
analogues. J Enzyme Inhib Med Chem. 2009 Feb;24(1):279-86.

2: Wan H, Wang Q, Chen X, Zeng Q, Shao Y, Fang H, Liao X, Li HS, Liu MG, Xu TL,
Diao M, Li D, Meng B, Tang B, Zhang Z, Liao L. WDR45 contributes to
neurodegeneration through regulation of ER homeostasis and neuronal death.
Autophagy. 2020 Mar;16(3):531-547.

3: Petrovic J, Hall H, Mehr R, Glas R, Höglund P. Inhibition of the proteasome
reduces transfer-induced diabetes in nonobese diabetic mice. Scand J Immunol.
2004 Jul-Aug;60(1-2):134-42.

4: Naujokat C, Sezer O, Zinke H, Leclere A, Hauptmann S, Possinger K. Proteasome
inhibitors induced caspase-dependent apoptosis and accumulation of p21WAF1/Cip1
in human immature leukemic cells. Eur J Haematol. 2000 Oct;65(4):221-36.

5: Huan JY, Streicher JM, Bleyle LA, Koop DR. Proteasome-dependent degradation
of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells.
Toxicol Appl Pharmacol. 2004 Sep 15;199(3):332-43.

6: Chase BI, Zhou Y, Xiang Y, Silverman RH, Zhou A. Proteasome-mediated
degradation of RNase L in response to phorbol-12-myristate-13-acetate (PMA)
treatment of mouse L929 cells. J Interferon Cytokine Res. 2003
Oct;23(10):565-73.

7: Stalker TJ, Skvarka CB, Scalia R. A novel role for calpains in the
endothelial dysfunction of hyperglycemia. FASEB J. 2003 Aug;17(11):1511-3.

8: Vega A, Chacón P, Alba G, El Bekay R, Martín-Nieto J, Sobrino F. Modulation
of IgE-dependent COX-2 gene expression by reactive oxygen species in human
neutrophils. J Leukoc Biol. 2006 Jul;80(1):152-63.

9: Yadav PN, Chaturvedi K, Howells RD. Inhibition of agonist-induced down-
regulation of the delta-opioid receptor with a proteasome inhibitor attenuates
opioid tolerance in human embryonic kidney 293 cells. J Pharmacol Exp Ther. 2007
Mar;320(3):1186-94.

10: Yajima Y, Sato M, Sorimachi H, Inomata M, Maki M, Kawashima S. Calpain
system regulates the differentiation of adult primitive mesenchymal ST-13
adipocytes. Endocrinology. 2006 Oct;147(10):4811-9.

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