Antiproliferative Factor Sialoglycopeptide

Description

Antiproliferative Factor Sialoglycopeptide
Catalog number: MDP0893
Name: O-(Acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2 –> 3)-O-beta-D-galactopyranosyl-(1 –> 3)-O-alpha-2-acetamido-2-deoxy-D-galactopyranosyl-(1 –> O)-Thr-Val-Pro-Ala-Ala-Val-Val-Val-Ala
Other name(s): Antiproliferative Factor Sialoglycopeptide
Molecular Formula: C₆₃H₁₀₇N₁₁O₂₉
Molecular Mass: 1482.6
Storage Temperature: -20C
Indication for Use:
This product if for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use.

Safety:
User must review the Material Safety Data Sheet (MSDS) provided with this product. In addition, this product should not be ingested, inhaled, swallowed or put in contact with eyes, skin or clothes.

References:

1: Keay SK, Szekely Z, Conrads TP, Veenstra TD, Barchi JJ Jr, Zhang CO, Koch KR,
Michejda CJ. An antiproliferative factor from interstitial cystitis patients is
a frizzled 8 protein-related sialoglycopeptide. Proc Natl Acad Sci U S A. 2004
Aug 10;101(32):11803-8.

2: Matika CA, Wasilewski M, Arnott JA, Planey SL. Antiproliferative factor
regulates connective tissue growth factor (CTGF/CCN2) expression in T24 bladder
carcinoma cells. Mol Biol Cell. 2012 May;23(10):1976-85.

3: Chavda B, Ling J, Majernick T, Planey SL. Antiproliferative factor (APF)
binds specifically to sites within the cytoskeleton-associated protein 4 (CKAP4)
extracellular domain. BMC Biochem. 2017 Sep 11;18(1):13.

4: Wein AJ. An antiproliferative factor from interstitial cystitis patients is a
frizzled 8 protein-related sialoglycopeptide. J Urol. 2005 Mar;173(3):909-10.

5: Zacharias DA, Mullen M, Planey SL. Antiproliferative factor-induced changes
in phosphorylation and palmitoylation of cytoskeleton-associated protein-4
regulate its nuclear translocation and DNA binding. Int J Cell Biol.
2012;2012:150918.

6: Grigorescu B, Powers K, Lazarou G. Update on Urinary Tract Markers in
Interstitial Cystitis/Bladder Pain Syndrome. Female Pelvic Med Reconstr Surg.
2016 Jan-Feb;22(1):16-23.

7: Kim J, Keay SK, Dimitrakov JD, Freeman MR. p53 mediates interstitial cystitis
antiproliferative factor (APF)-induced growth inhibition of human urothelial
cells. FEBS Lett. 2007 Aug 7;581(20):3795-9.

8: Kim J, Keay SK, You S, Loda M, Freeman MR. A synthetic form of frizzled
8-associated antiproliferative factor enhances p53 stability through USP2a and
MDM2. PLoS One. 2012;7(12):e50392.

9: Koch KR, Zhang CO, Kaczmarek P, Barchi J Jr, Guo L, Shahjee HM, Keay S. The
effect of a novel frizzled 8-related antiproliferative factor on in vitro
carcinoma and melanoma cell proliferation and invasion. Invest New Drugs. 2012
Oct;30(5):1849-64.

10: Conrads TP, Tocci GM, Hood BL, Zhang CO, Guo L, Koch KR, Michejda CJ,
Veenstra TD, Keay SK. CKAP4/p63 is a receptor for the frizzled-8 protein-related
antiproliferative factor from interstitial cystitis patients. J Biol Chem. 2006
Dec 8;281(49):37836-43.

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