Alpha-Ketoglutarate (Highly Pure)

Product Description

Alpha-Ketoglutarate (Highly Pure)
Catalog number: B2013929
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 mg
Molecular Weight or Concentration: 190.1
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: −20°C
Keywords: alpha-Ketoglutarate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice Cell Metab. 2020 Sep 1;32(3):447-456.e6.
2: Gyanwali B, Lim ZX, Soh J, Lim C, Guan SP, Goh J, Maier AB, Kennedy BK. Alpha-Ketoglutarate dietary supplementation to improve health in humans Trends Endocrinol Metab. 2022 Feb;33(2):136-146.
3: Baracco EE, Castoldi F, Durand S, Enot DP, Tadic J, Kainz K, Madeo F, Chery A, Izzo V, Maiuri MC, Pietrocola F, Kroemer G. -Ketoglutarate inhibits autophagy Aging (Albany NY). 2019 Jun 7;11(11):3418-3431.
4: Zhou W, Hu G, He J, Wang T, Zuo Y, Cao Y, Zheng Q, Tu J, Ma J, Cai R, Chen Y, Fan Q, Dong B, Tan H, Wang Q, Xue W, Cheng J. SENP1-Sirt3 signaling promotes -ketoglutarate production during M2 macrophage polarization Cell Rep. 2022 Apr 12;39(2):110660.
5: Xiao D, Zeng L, Yao K, Kong X, Wu G, Yin Y. The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications Amino Acids. 2016 Sep;48(9):2067-80.
6: Zhang Z, He C, Gao Y, Zhang L, Song Y, Zhu T, Zhu K, Lv D, Wang J, Tian X, Ma T, Ji P, Cui W, Liu G. -ketoglutarate delays age-related fertility decline in mammals Aging Cell. 2021 Feb;20(2):e13291.
7: Liu S, Yang J, Wu Z. The Regulatory Role of -Ketoglutarate Metabolism in Macrophages Mediators Inflamm. 2021 Mar 29;2021:5577577.
8: Papadopoulou A, Meyer F, Buller RM. Engineering Fe(II)/-Ketoglutarate-Dependent Halogenases and Desaturases Biochemistry. 2023 Jan 17;62(2):229-240.
9: Tao H, Abe I. Harnessing Fe(II)/-ketoglutarate-dependent oxygenases for structural diversification of fungal meroterpenoids Curr Opin Biotechnol. 2022 Oct;77:102763.
10: Legendre F, MacLean A, Appanna VP, Appanna VD. Biochemical pathways to -ketoglutarate, a multi-faceted metabolite World J Microbiol Biotechnol. 2020 Jul 20;36(8):123.

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