β-Sheet Breaker Peptide iAβ5

Product Description

β-Sheet Breaker Peptide iAβ5
Catalog number: MDP0727
CAS Number: N/A
Sequence: Leu-Pro-Phe-Phe-Asp
Amount: 1 mg
Molecular Weight: 637.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Kanchi PK, Dasmahapatra AK. Enhancing the binding of the β-sheet breaker peptide LPFFD to the amyloid-β fibrils by aromatic modifications: A molecular dynamics simulation study Comput Biol Chem. 2021 Jun;92:107471.
2: Stellato F, Fusco Z, Chiaraluce R, Consalvi V, Dinarelli S, Placidi E, Petrosino M, Rossi GC, Minicozzi V, Morante S. The effect of β-sheet breaker peptides on metal associated Amyloid-β peptide aggregation process Biophys Chem. 2017 Oct;229:110-114.
3: Murvai U, Soós K, Penke B, Kellermayer MS. Effect of the beta-sheet-breaker peptide LPFFD on oriented network of amyloid β25-35 fibrils J Mol Recognit. 2011 May-Jun;24(3):453-60.
4: Vitiello G, Grimaldi M, Ramunno A, Ortona O, De Martino G, D’Ursi AM, D’Errico G. Interaction of a beta-sheet breaker peptide with lipid membranes J Pept Sci. 2010 Feb;16(2):115-22.
5: Chacón MA, Barría MI, Soto C, Inestrosa NC. Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits Mol Psychiatry. 2004 Oct;9(10):953-61.
6: Rocha S, Cardoso I, Börner H, Pereira MC, Saraiva MJ, Coelho M. Design and biological activity of beta-sheet breaker peptide conjugates Biochem Biophys Res Commun. 2009 Mar 6;380(2):397-401.
7: Jarmuła A, Stępkowski D. The β-sheet breakers and π-stacking J Pept Sci. 2013 Jun;19(6):345-9.
8: Vitiello G, Grimaldi M, D’Ursi AM, D’Errico G. The iAβ5p β-breaker peptide regulates the Aβ(25-35) interaction with lipid bilayers through a cholesterol-mediated mechanism Biochem Biophys Res Commun. 2012 Jan 6;417(1):88-92.
9: Okada Y, Wakamatsu H, Sugai M, Kauppinen EI, Chiba K. Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis Org Lett. 2015 Sep 4;17(17):4264-7.
10: Adessi C, Frossard MJ, Boissard C, Fraga S, Bieler S, Ruckle T, Vilbois F, Robinson SM, Mutter M, Banks WA, Soto C. Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer’s disease J Biol Chem. 2003 Apr 18;278(16):13905-11.

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