α-Conotoxin GI

Product Description

α-Conotoxin GI
Catalog number: MDP0494
CAS Number: 120972-53-4
Sequence: Glu-Cys-Cys-Asn-Pro-Ala-Cys-Gly-Arg-His-Tyr-Ser-Cys-NH2 (Disulfide bonds between Cys2-Cys7 and Cys3-Cys13)
Amount: 500 ug
Molecular Weight: 1437.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Blount K, Johnson A, Prior C, Marshall IG. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction Toxicon. 1992 Aug;30(8):835-42.
2: Yu S, Yang B, Yan L, Dai Q. Sensitive Detection of α-Conotoxin GI in Human Plasma Using a Solid-Phase Extraction Column and LC-MS/MS Toxins (Basel). 2017 Jul 28;9(8):235.
3: Gray WR, Luque FA, Galyean R, Atherton E, Sheppard RC, Stone BL, Reyes A, Alford J, McIntosh M, Olivera BM, et al. Conotoxin GI: disulfide bridges, synthesis, and preparation of iodinated derivatives Biochemistry. 1984 Jun 5;23(12):2796-802.
4: Ning J, Li R, Ren J, Zhangsun D, Zhu X, Wu Y, Luo S. Alanine-Scanning Mutagenesis of α-Conotoxin GI Reveals the Residues Crucial for Activity at the Muscle Acetylcholine Receptor Mar Drugs. 2018 Dec 13;16(12):507.
5: Kasheverov IE, Chiara DC, Zhmak MN, Maslennikov IV, Pashkov VS, Arseniev AS, Utkin YN, Cohen JB, Tsetlin VI. alpha-Conotoxin GI benzoylphenylalanine derivatives. (1)H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor FEBS J. 2006 Apr;273(7):1373-88.
6: McManus OB, Musick JR. Postsynaptic block of frog neuromuscular transmission by conotoxin GI J Neurosci. 1985 Jan;5(1):110-6.
7: Stiles BG, Sexton FW. Immunoreactivity, epitope mapping and protection studies with anti-conotoxin GI sera and various conotoxins Toxicon. 1992 Apr;30(4):367-77.
8: Kaerner A, Rabenstein DL. Stability and structure-forming properties of the two disulfide bonds of alpha-conotoxin GI Biochemistry. 1999 Apr 27;38(17):5459-70.
9: Gehrmann J, Alewood PF, Craik DJ. Structure determination of the three disulfide bond isomers of alpha-conotoxin GI: a model for the role of disulfide bonds in structural stability J Mol Biol. 1998 May 1;278(2):401-15.
10: Pivovarov AS, Palikhova TA, Nikolaev GM, Velikanov AN, Vasilieva NA, Kasheverov IE, Utkin YN, Tsetlin VI. Atypical Acetylcholine Receptors on the Neurons of the Turkish Snail Dokl Biochem Biophys. 2020 Mar;491(1):81-84.

Products Related to α-Conotoxin GI can be found at Peptides