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6-Azauracil (Highly Pure)

Original price was: $1,395.00.Current price is: $695.00.

Catalog Number: B2016508 (10 g)
6-Azauracil (Highly Pure) is a high quality chemical compound that is a derivative of uracil. It is a potent inhibitor of orotidine-5′-phosphate decarboxylase, an enzyme involved in the biosynthesis of pyrimidine nucleotides. 6-Azauracil is commonly used in research to study nucleotide metabolism and as a tool in drug discovery. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Product Description

6-Azauracil (Highly Pure)
Catalog number: B2016508
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 g
Molecular Weight or Concentration: 113.08 g/mol
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: −20°C
Keywords: 1,2,4-Triazine-3,5-dione; 3,5-Dihydroxy-1,2,4-triazine
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Tansey WP. 6-azauracil sensitivity assay for yeast CSH Protoc. 2006 Dec 1;2006(7):pdb.prot4613.
2: Gobbo JP, Borin AC, Serrano-Andrés L. On the relaxation mechanisms of 6-azauracil J Phys Chem B. 2011 May 19;115(19):6243-51.
3: Chen J, Buonaugurio A, Dolgounitcheva O, Zakrzewski VG, Bowen KH, Ortiz JV. Photoelectron spectroscopy of the 6-azauracil anion J Phys Chem A. 2013 Feb 14;117(6):1079-82.
4: Exinger F, Lacroute F. 6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiae Curr Genet. 1992 Jul;22(1):9-11.
5: Tamaki N, Kubo K, Aoyama H, Funatsuka A. Inhibitory effect of 6-azauracil on purified rabbit liver 4-aminobutyrate aminotransferase J Biochem. 1983 Apr;93(4):955-9.
6: Seela F, Chittepu P. 6-Azauracil or 8-aza-7-deazaadenine nucleosides and oligonucleotides: the effect of 2′-fluoro substituents and nucleobase nitrogens on conformation and base pairing Org Biomol Chem. 2008 Feb 7;6(3):596-607.
7: Jones GE. 6-azauracil-resistant variants of cultured plant cells lack uracil phosphoribosyltransferase activity Plant Physiol. 1984 May;75(1):161-5.
8: Rizki RM, Rizki TM. Morphogenetic effects of 6-azauracil and 6-azauridine Science. 1965 Oct 8;150(3693):222-3.
9: Zhou H, Liu Q, Shi T, Yu Y, Lu H. Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation Yeast. 2015 Oct;32(10):643-55.
10: WELCH AD, HANDSCHUMACHER RE, JAFFE JJ. Studies on the pharmacology of 6-azauracil J Pharmacol Exp Ther. 1960 Jul;129:262-70.

Products Related to 6-Azauracil (Highly Pure) can be found at Chemicals

Additional Information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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