5-Aminovaleric Acid

Product Description

5-Aminovaleric Acid
Catalog number: B2015817
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 g
Molecular Weight or Concentration: 117.15
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: RT, dry
Keywords: 5-AVA, 5-Aminopentanoic acid, Homopiperidinic acid
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Zhao M, Wei H, Li C, Zhan R, Liu C, Gao J, Yi Y, Cui X, Shan W, Ji L, Pan B, Cheng S, Song M, Sun H, Jiang H, Cai J, Garcia-Barrio MT, Chen YE, Meng X, Dong E, Wang DW, Zheng L. Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy Nat Commun. 2022 Apr 1;13(1):1757.
2: Haikonen R, Kärkkäinen O, Koistinen V, Hanhineva K. Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease Trends Endocrinol Metab. 2022 Jul;33(7):463-480.
3: Haberbosch L, Kierszniowska S, Willmitzer L, Mai K, Spranger J, Maurer L. 5-Aminovaleric acid betaine predicts impaired glucose metabolism and diabetes Nutr Diabetes. 2023 Sep 20;13(1):17.
4: Yang SY, Choi TR, Jung HR, Park YL, Han YH, Song HS, Bhatia SK, Park K, Ahn JO, Jeon WY, Kim JS, Yang YH. Production of glutaric acid from 5-aminovaleric acid by robust whole-cell immobilized with polyvinyl alcohol and polyethylene glycol Enzyme Microb Technol. 2019 Sep;128:72-78.
5: Hong YG, Moon YM, Hong JW, No SY, Choi TR, Jung HR, Yang SY, Bhatia SK, Ahn JO, Park KM, Yang YH. Production of glutaric acid from 5_aminovaleric acid using Escherichia coli whole cell bio-catalyst overexpressing GabTD from Bacillus subtilis Enzyme Microb Technol. 2018 Nov;118:57-65.
6: Dhaher R, Damisah EC, Wang H, Gruenbaum SE, Ong C, Zaveri HP, Gruenbaum BF, Eid T. 5_aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy Neurobiol Dis. 2014 Jul;67:18-23.
7: Luzzi S, Maggi CA, Spagnesi S, Santicioli P, Zilletti L. 5_Aminovaleric acid interactions with GABAA and GABAB receptors in guinea-pig ileum J Auton Pharmacol. 1985 Mar;5(1):65-9.
8: Shin JH, Park SH, Oh YH, Choi JW, Lee MH, Cho JS, Jeong KJ, Joo JC, Yu J, Park SJ, Lee SY. Metabolic engineering of Corynebacterium glutamicum for enhanced production of 5_aminovaleric acid Microb Cell Fact. 2016 Oct 7;15(1):174.
9: Kristiansen U, Hedegaard A, Herdeis C, Lund TM, Nielsen B, Hansen JJ, Falch E, Hjeds H, Krogsgaard-Larsen P. Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships J Neurochem. 1992 Mar;58(3):1150-9.
10: Joo JC, Oh YH, Yu JH, Hyun SM, Khang TU, Kang KH, Song BK, Park K, Oh MK, Lee SY, Park SJ. Production of 5-aminovaleric acid in recombinant Corynebacterium glutamicum strains from a Miscanthus hydrolysate solution prepared by a newly developed Miscanthus hydrolysis process Bioresour Technol. 2017 Dec;245(Pt B):1692-1700.

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