4-Nitrophenyl α-D-Mannopyranoside


Catalog Number: B2012272 (100 mg)
4-Nitrophenyl α-D-Mannopyranoside is a high quality Substrate for α-Mannosidase. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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4-Nitrophenyl α-D-Mannopyranoside
Catalog number: B2012272
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 mg
Molecular Weight or Concentration: 301.3 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20C
Keywords: 4-Nitrophenyl α-D-Mannopyranoside
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Kanellopoulos PN, Pavlou K, Perrakis A, Agianian B, Vorgias CE, Mavrommatis C, Soufi M, Tucker PA, Hamodrakas SJ. The crystal structure of the complexes of concanavalin A with 4′-nitrophenyl-alpha-D-mannopyranoside and 4′-nitrophenyl-alpha-D-glucopyranoside J Struct Biol. 1996 May-Jun;116(3):345-55.
2: Speciale G, Farren-Dai M, Shidmoossavee FS, Williams SJ, Bennet AJ. C2-Oxyanion Neighboring Group Participation: Transition State Structure for the Hydroxide-Promoted Hydrolysis of 4-Nitrophenyl α-d-Mannopyranoside J Am Chem Soc. 2016 Oct 26;138(42):14012-14019.
3: Abgottspon D, Rölli G, Hosch L, Steinhuber A, Jiang X, Schwardt O, Cutting B, Smiesko M, Jenal U, Ernst B, Trampuz A. Development of an aggregation assay to screen FimH antagonists J Microbiol Methods. 2010 Sep;82(3):249-55.
4: Hamodrakas SJ, Alexandraki E, Troganis A, Stassinopoulou CI. Models of binding of 4′-nitrophenyl alpha-D-mannopyranoside to the lectin concanavalin A Int J Biol Macromol. 1989 Feb;11(1):17-22.
5: Rajesh T, Jeon JM, Song E, Park HM, Seo HM, Kim HJ, Yi DH, Kim YH, Choi KY, Kim YG, Park HY, Lee YK, Yang YH. Putative role of a Streptomyces coelicolor-derived α-mannosidase in deglycosylation and antibiotic production Appl Biochem Biotechnol. 2014 Feb;172(3):1639-51.
6: Jelinek-Kelly S, Akiyama T, Saunier B, Tkacz JS, Herscovics A. Characterization of a specific alpha-mannosidase involved in oligosaccharide processing in Saccharomyces cerevisiae J Biol Chem. 1985 Feb 25;260(4):2253-7.
7: Madiyalakan R, Piskorz CF, Piver MS, Matta KL. Serum beta-(1—-4)-galactosyltransferase activity with synthetic low molecular weight acceptor in human ovarian cancer Eur J Cancer Clin Oncol. 1987 Jul;23(7):901-6.
8: Howard S, Braun C, McCarter J, Moremen KW, Liao YF, Withers SG. Human lysosomal and jack bean alpha-mannosidases are retaining glycosidases Biochem Biophys Res Commun. 1997 Sep 29;238(3):896-8.
9: Hansen DK, Webb H, Nielsen JW, Harris P, Winther JR, Willemoës M. Mutational analysis of divalent metal ion binding in the active site of class II α-mannosidase from Sulfolobus solfataricus Biochemistry. 2015 Mar 24;54(11):2032-9.
10: Ohyama Y, Kasai K, Nomoto H, Inoue Y. Frontal affinity chromatography of ovalbumin glycoasparagines on a concanavalin A-sepharose column. A quantitative study of the binding specificity of the lectin J Biol Chem. 1985 Jun 10;260(11):6882-7.

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