(2-Hydroxypropyl)-γ-cyclodextrin (Highly Pure)


Catalog Number: B2010647 (1 g)
(2-Hydroxypropyl)-γ-cyclodextrin (Highly Pure) is a highly pure water-soluble alkylated gamma cyclodextrin. This product has been used as solubilizing agent and versatile molecular tool for various applications. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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(2-Hydroxypropyl)-γ-cyclodextrin (Highly Pure)
Catalog number: B2010647
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 g
Molecular Weight or Concentration: na
Supplied as: Powder
Applications: solubilizing agent and versatile molecular tool for various applications
Storage: RT
Keywords: (2-hydroxypropyl)-gamma-cyclodextrin, HGC, 2-OH-gamma cyclodextrin
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Singhal A, Krystofiak ES, Jerome WG, Song B. 2-Hydroxypropyl-gamma-
cyclodextrin overcomes NPC1 deficiency by enhancing lysosome-ER association and
autophagy. Sci Rep. 2020 May 26;10(1):8663.

2: Hollow SE, Johnstone TC. Encapsulation of closo-dodecaiodododecaborate
in 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis. Chem Commun (Camb). 2022
Jan 26.

3: Hoque S, Kondo Y, Sakata N, Yamada Y, Fukaura M, Higashi T, Motoyama K, Arima
H, Higaki K, Hayashi A, Komiya T, Ishitsuka Y, Irie T. Differential Effects of
2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells.
Int J Mol Sci. 2020 Jan 30;21(3):898.

4: Sursyakova VV, Levdansky VA, Rubaylo AI. Strong complexation of water-soluble
betulin derivatives with (2-hydroxypropyl)-γ-cyclodextrin studied by affinity
capillary electrophoresis. Electrophoresis. 2020 Jan;41(1-2):112-115.

5: Huang H, Tang G, Wang Q, Li D, Shen F, Zhou J, Yu H. Two novel non-viral gene
delivery vectors: low molecular weight polyethylenimine cross-linked by
(2-hydroxypropyl)-beta-cyclodextrin or (2-hydroxypropyl)-gamma-cyclodextrin.
Chem Commun (Camb). 2006 Jun 14;(22):2382-4.

6: Yamada Y, Ishitsuka Y, Kondo Y, Nakahara S, Nishiyama A, Takeo T, Nakagata N,
Motoyama K, Higashi T, Arima H, Kamei S, Shuto T, Kai H, Hayashino Y, Sugita M,
Kikuchi T, Hirata F, Miwa T, Takeda H, Orita Y, Seki T, Ohta T, Kurauchi Y,
Katsuki H, Matsuo M, Higaki K, Ohno K, Matsumoto S, Era T, Irie T. Differential
mode of cholesterol inclusion with 2-hydroxypropyl-cyclodextrins increases
safety margin in treatment of Niemann-Pick disease type C. Br J Pharmacol. 2021

7: Blum W, Aichholz R, Ramstein P, Fetz A, Raschdorf F. Determination of
2-hydroxypropyl-gamma-cyclodextrin in plasma of cynomolgus monkeys after oral
administration by gas chromatography-mass spectrometry. J Chromatogr B Biomed
Sci Appl. 1998 Dec 11;720(1-2):171-8.
8: Wathoni N, Motoyama K, Higashi T, Okajima M, Kaneko T, Arima H. Enhancement
of curcumin wound healing ability by complexation with 2-hydroxypropyl-γ-
cyclodextrin in sacran hydrogel film. Int J Biol Macromol. 2017 May;98:268-276.

9: Trapani G, Latrofa A, Franco M, Pantaleo MR, Sanna E, Massa F, Tuveri F, Liso
G. Complexation of zolpidem with 2-hydroxypropyl-beta-, methyl-beta-, and
2-hydroxypropyl-gamma-cyclodextrin: effect on aqueous solubility, dissolution
rate, and ataxic activity in rat. J Pharm Sci. 2000 Nov;89(11):1443-51.
10: Motoyama K, Higashi T, Okajima MK, Kaneko T, Arima H. [Potential Use of
Sacran Hydrogels as Wound Dressing Material]. Yakugaku Zasshi.

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