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2′-Deoxythymidine (Highly Pure)

Original price was: $1,195.00.Current price is: $595.00.

Catalog Number: B2018181 (1 g)
2′-Deoxythymidine, also known as thymidine, is a nucleoside that is composed of the nucleobase thymine linked to a deoxyribose sugar molecule. It is one of the building blocks of DNA and plays a crucial role in the genetic information storage and replication processes within cells. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2018181 Category: Tag:

Product Description

5/5 - (1 vote)

2′-Deoxythymidine (Highly Pure)
Catalog number: B2018181
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 g
Molecular Weight or Concentration: 242.2
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: RT
Keywords: thymidine
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Lopez-Gomez C, Levy RJ, Sanchez-Quintero MJ, Juanola-Falgarona M, Barca E, Garcia-Diaz B, Tadesse S, Garone C, Hirano M. Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency Ann Neurol. 2017 May;81(5):641-652.
2: Ankit, Kumar R, Wang T, Veedu RN, Kumar S. Novel 3′-[4-fluoroaryl-(1,2,3-triazol-1-yl)]-3′-deoxythymidine analogues: Design, synthesis, characterization and their potential as anticancer agents Nucleosides Nucleotides Nucleic Acids. 2022;41(4):343-360.
3: Pierra C, Dukhan D, Gosselin G, Sommadossi JP. Synthesis of beta-L-2′-deoxythymidine (L-dT) Curr Protoc Nucleic Acid Chem. 2006 Apr;Chapter 14:Unit 14.3.
4: Kleczewska N, Ruszkowski P, Singh A, Trznadel R, Celewicz L. Synthesis and anticancer activity of 3′-[4-fluoroaryl-(1,2,3-triazol-1-yl)]-3′-deoxythymidine analogs and their phosphoramidates Nucleosides Nucleotides Nucleic Acids. 2019;38(9):605-641.
5: Zidovudine (AZT) Lancet. 1987 Apr 25;1(8539):957-8.
6: McManus FP, O’Flaherty DK, Noronha AM, Wilds CJ. O4-alkyl-2′-deoxythymidine cross-linked DNA to probe recognition and repair by O6-alkylguanine DNA alkyltransferases Org Biomol Chem. 2012 Sep 21;10(35):7078-90.
7: Antunes AM, Wolf B, Oliveira MC, Beland FA, Marques MM. 2′-Deoxythymidine adducts from the anti-HIV drug nevirapine Molecules. 2013 Apr 26;18(5):4955-71.
8: Burkhart BM, Papchikhin A, Chattopadhyaya J, Sundaralingam M. 2′,3′-Dideoxy-3′-C,2′-N-[(3R,5R)-5-ethoxy-carbonyl-2-methyl-1, 2-isoxazolidine]-ribothymidine Acta Crystallogr C. 1995 Jul 15;51 ( Pt 7):1462-4.
9: Østergaard ME, Kumar P, Nichols J, Watt A, Sharma PK, Nielsen P, Seth PP. Allele-Selective Inhibition of Mutant Huntingtin with 2-Thio- and C5- Triazolylphenyl-Deoxythymidine-Modified Antisense Oligonucleotides Nucleic Acid Ther. 2015 Oct;25(5):266-74.
10: Hellendahl KF, Kaspar F, Zhou X, Yang Z, Huang Z, Neubauer P, Kurreck A. Optimized Biocatalytic Synthesis of 2-Selenopyrimidine Nucleosides by Transglycosylation* Chembiochem. 2021 Jun 2;22(11):2002-2009.

Products Related to 2′-Deoxythymidine (Highly Pure) can be found at Chemicals

Additional Information

Weight 0.8 oz
Dimensions 2 × 0.9 × 0.9 in
5/5 - (1 vote)

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