11β-HSD1 HDR Plasmid

Product Description

11β-HSD1 HDR Plasmid
Catalog number: B2015173
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: N/A
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: 2 – 8 °C
Keywords: 11β-HSD1 HDR Plasmid
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Odermatt A, Nashev LG. The glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 has broad substrate specificity: Physiological and toxicological considerations J Steroid Biochem Mol Biol. 2010 Mar;119(1-2):1-13.
2: Burns DM, He C, Li YL, Zhuo J, Qian DQ, Chen L, Jalluri R, Diamond S, Covington MB, Li Y, Wynn R, Scherle P, Yeleswaram S, Hollis G, Friedman S, Metcalf B, Yao W. Discovery of a novel 2-spiroproline steroid mimetic scaffold for the potent inhibition of 11β-HSD1 Bioorg Med Chem Lett. 2022 Oct 1;73:128884.
3: Hassan-Smith ZK, Morgan SA, Sherlock M, Hughes B, Taylor AE, Lavery GG, Tomlinson JW, Stewart PM. Gender-Specific Differences in Skeletal Muscle 11β-HSD1 Expression Across Healthy Aging J Clin Endocrinol Metab. 2015 Jul;100(7):2673-81.
4: Harno E, Cottrell EC, Yu A, DeSchoolmeester J, Gutierrez PM, Denn M, Swales JG, Goldberg FW, Bohlooly-Y M, Andersén H, Wild MJ, Turnbull AV, Leighton B, White A. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms Endocrinology. 2013 Dec;154(12):4580-93.
5: Cooper MS, Stewart PM. 11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation J Clin Endocrinol Metab. 2009 Dec;94(12):4645-54.
6: Li F, Zhou C, Gao M, Xu L, Wen G, Zhao J, Yan J. Effect of 11β-HSD1 inhibitor on bone microstructure and bone density in rats with femoral head necrosis J Musculoskelet Neuronal Interact. 2020 Jun 1;20(2):282-290.
7: Konstantakou P, Mastorakos G, Vrachnis N, Tomlinson JW, Valsamakis G. Dysregulation of 11beta-hydroxysteroid dehydrogenases: implications during pregnancy and beyond J Matern Fetal Neonatal Med. 2017 Feb;30(3):284-293.
8: Wang GC, Yu JH, Shen Y, Leng Y, Zhang H, Yue JM. Limonoids and Triterpenoids as 11β-HSD1 Inhibitors from Walsura robusta J Nat Prod. 2016 Apr 22;79(4):899-906.
9: Fürst-Recktenwald S, Dörr HG, Quinkler M, Dötsch J, Stewart PM. Is there sufficient evidence to consider the use of 11β-hydroxysteroid dehydrogenase type 1 inhibition in children? Clin Endocrinol (Oxf). 2012 Aug;77(2):159-68.
10: Dodd S, Skvarc DR, Dean OM, Anderson A, Kotowicz M, Berk M. Effect of Glucocorticoid and 11β-Hydroxysteroid-Dehydrogenase Type 1 (11β-HSD1) in Neurological and Psychiatric Disorders Int J Neuropsychopharmacol. 2022 May 27;25(5):387-398.

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