11β-HSD1 Double Nickase Plasmid

Product Description

11β-HSD1 Double Nickase Plasmid
Catalog number: B2015198
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 ug
Molecular Weight or Concentration: N/A
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: 2 – 8 °C
Keywords: 11β-HSD1 Double Nickase Plasmid
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Davidson CT, Miller E, Muir M, Dawson JC, Lee M, Aitken S, Serrels A, Webster SP, Homer NZM, Andrew R, Brunton VG, Hadoke PWF, Walker BR. 11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis PLoS One. 2023 Mar 20;18(3):e0255709.
2: Caughey S, Harris AP, Seckl JR, Holmes MC, Yau JL. Forebrain-Specific Transgene Rescue of 11β-HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain-Derived Neurotrophic Factor mRNA Levels in Aged 11β-HSD1 Deficient Mice J Neuroendocrinol. 2017 Jan;29(1):10.1111/jne.12447.
3: Koh EH, Kim AR, Kim H, Kim JH, Park HS, Ko MS, Kim MO, Kim HJ, Kim BJ, Yoo HJ, Kim SJ, Oh JS, Woo CY, Jang JE, Leem J, Cho MH, Lee KU. 11β-HSD1 reduces metabolic efficacy and adiponectin synthesis in hypertrophic adipocytes J Endocrinol. 2015 Jun;225(3):147-58.
4: Muller C, Hennebert O, Morfin R. The native anti-glucocorticoid paradigm J Steroid Biochem Mol Biol. 2006 Jul;100(1-3):95-105.
5: Peng K, Pan Y, Li J, Khan Z, Fan M, Yin H, Tong C, Zhao Y, Liang G, Zheng C. 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes Sci Rep. 2016 Nov 14;6:37160.
6: Abbas A, Schini M, Ainsworth G, Brown SR, Oughton J, Crowley RK, Cooper MS, Fairclough RJ, Eastell R, Stewart PM. Effect of AZD4017, a Selective 11β-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia J Clin Endocrinol Metab. 2022 Jun 16;107(7):2026-2035.
7: Na YJ, Choi KJ, Jung WH, Park SB, Kang S, Ahn JH, Kim KY. A Novel Selective 11β-HSD1 Inhibitor, (E)-4-(2-(6-(2,6-Dichloro-4-(Trifluoromethyl)Phenyl)-4-Methyl-1,1-Dioxido-1,2,6-Thiadiazinan-2-yl)Acetamido)Adamantan-1-Carboxamide (KR-67607), Prevents BAC-Induced Dry Eye Syndrome Int J Mol Sci. 2020 May 25;21(10):3729.
8: Wu H, Zhu Q, Li X, He Y, Wang Y, Lu Y, Qi J, Ding Y, Li J, Xu R, Sun Y. The upregulation of 11β-HSD1 in ovarian granulosa cells by cortisol and interleukin-1β in polycystic ovary syndrome Gynecol Endocrinol. 2020 Aug;36(8):668-672.
9: Liu J, Kong X, Wang L, Qi H, Di W, Zhang X, Wu L, Chen X, Yu J, Zha J, Lv S, Zhang A, Cheng P, Hu M, Li Y, Bi J, Li Y, Hu F, Zhong Y, Xu Y, Ding G. Essential roles of 11β-HSD1 in regulating brown adipocyte function J Mol Endocrinol. 2013 Jan 11;50(1):103-13.
10: Lai W, Tian X, Xiang Q, Chu K, Wei Y, Deng J, Zhang S, Brown J, Hong G. 11β-HSD1 modulates LPS-induced innate immune responses in adipocytes by altering expression of PTEN Mol Endocrinol. 2015 Apr;29(4):558-70.

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