11β-HSD1 Double Nickase Plasmid

Product Description

11β-HSD1 Double Nickase Plasmid
Catalog number: B2015154
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: N/A
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: 2-8 °C
Keywords: 11β-HSD1 Double Nickase Plasmid
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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2: Zhou HY, Hu GX, Lian QQ, Morris D, Ge RS. The metabolism of steroids, toxins and drugs by 11β-hydroxysteroid dehydrogenase 1 Toxicology. 2012 Feb 6;292(1):1-12.
3: Dammann C, Stapelfeld C, Maser E. Expression and activity of the cortisol-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 is tissue and species-specific Chem Biol Interact. 2019 Apr 25;303:57-61.
4: Kley M, Moser SO, Winter DV, Odermatt A. In vitro methods to assess 11β-hydroxysteroid dehydrogenase type 1 activity Methods Enzymol. 2023;689:121-165.
5: Shah U, Boyle CD, Chackalamannil S, Baker H, Kowalski T, Lee J, Terracina G, Zhang L. Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors Bioorg Med Chem Lett. 2010 Mar 1;20(5):1551-4.
6: Doig CL, Fletcher RS, Morgan SA, McCabe EL, Larner DP, Tomlinson JW, Stewart PM, Philp A, Lavery GG. 11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice Endocrinology. 2017 Jun 1;158(6):1964-1976.
7: Chapman KE, Coutinho AE, Gray M, Gilmour JS, Savill JS, Seckl JR. The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response Mol Cell Endocrinol. 2009 Mar 25;301(1-2):123-31.
8: Morgan SA, Berryman DE, List EO, Lavery GG, Stewart PM, Kopchick JJ. Regulation of 11β-HSD1 by GH/IGF-1 in key metabolic tissues may contribute to metabolic disease in GH deficient patients Growth Horm IGF Res. 2022 Feb;62:101440.
9: Odermatt A, Klusonova P. 11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story J Steroid Biochem Mol Biol. 2015 Jul;151:85-92.
10: Hu M, Han T, Pan Q, Ni D, Gao F, Wang L, Ren H, Zhang X, Jiao H, Wang Y, Dai D, Man Y, Tang W, Sun Y, Li W, Li J, Li G. The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11β-HSD1 Int J Biol Sci. 2022 Apr 30;18(8):3107-3121.

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