11β-HSD1 CRISPR Activation Plasmid

Product Description

11β-HSD1 CRISPR Activation Plasmid
Catalog number: B2015186
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: N/A
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: 2 – 8 °C
Keywords: 11β-HSD1 CRISPR Activation Plasmid
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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2: Kragl A, Schoon J, Tzvetkova A, Wenzel C, Blaschke M, Böcker W, Siggelkow H, Tzvetkov MV. Effects of HSD11B1 knockout and overexpression on local cortisol production and differentiation of mesenchymal stem cells Front Bioeng Biotechnol. 2022 Aug 25;10:953034.
3: Brooks K, Burns G, Spencer TE. Biological Roles of Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1), HSD11B2, and Glucocorticoid Receptor (NR3C1) in Sheep Conceptus Elongation Biol Reprod. 2015 Aug;93(2):38.
4: Li H, Hu S, Wu R, Zhou H, Zhang K, Li K, Lin W, Shi Q, Chen H, Lv S. 11β-Hydroxysteroid Dehydrogenase Type 1 Facilitates Osteoporosis by Turning on Osteoclastogenesis through Hippo Signaling Int J Biol Sci. 2023 Jul 15;19(11):3628-3639.
5: Taves MD, Otsuka S, Taylor MA, Donahue KM, Meyer TJ, Cam MC, Ashwell JD. Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth J Clin Invest. 2023 Sep 15;133(18):e164599.
6: Dineen RA, Martin-Grace J, Ahmed KMS, Taylor AE, Shaheen F, Schiffer L, Gilligan LC, Lavery GG, Frizelle I, Gunness A, Garrahy A, Hannon AM, Methlie P, Eystein SH, Stewart PM, Tomlinson JW, Hawley JM, Keevil BG, O’Reilly MW, Smith D, McDermott J, Healy ML, Agha A, Pazderska A, Gibney J, Behan LA, Thompson CJ, Arlt W, Sherlock M. Tissue Glucocorticoid Metabolism in Adrenal Insufficiency: A Prospective Study of Dual-release Hydrocortisone Therapy J Clin Endocrinol Metab. 2023 Nov 17;108(12):3178-3189.
7: Peng K, Pan Y, Li J, Khan Z, Fan M, Yin H, Tong C, Zhao Y, Liang G, Zheng C. 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes Sci Rep. 2016 Nov 14;6:37160.
8: Tsai KH, Cooper MS. Recycling glucocorticoids: therapeutic implications of the 11β-HSD1 enzyme system J Endocrinol. 2023 Aug 1;258(3):e220289.
9: Gathercole LL, Lavery GG, Morgan SA, Cooper MS, Sinclair AJ, Tomlinson JW, Stewart PM. 11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects Endocr Rev. 2013 Aug;34(4):525-55.
10: Gray GA, White CI, Castellan RF, McSweeney SJ, Chapman KE. Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium J Mol Endocrinol. 2017 Jan;58(1):R1-R13.

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