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Lithocholic Acid (Biotechnology Grade)

$195.00

Catalog Number: B2010631 (500 mg)
Lithocholic Acid (Biotechnology Grade) is a highly pure oligo(ethylene glycol) derivative of bile acids. This product has been used as multipurpose tool in the study of bile acids. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2010631 Categories: ,

Description

Lithocholic Acid (Biotechnology Grade)
Catalog number: B2010631
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 500 mg
Molecular Weight or Concentration: 376.57 g/mol
Supplied as: Solid
Applications: multipurpose tool in the study of bile acids
Storage: RT
Keywords: 3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Sasaki H, Masuno H, Kawasaki H, Yoshihara A, Numoto N, Ito N, Ishida H,
Yamamoto K, Hirata N, Kanda Y, Kawachi E, Kagechika H, Tanatani A. Lithocholic
Acid Derivatives as Potent Vitamin D Receptor Agonists. J Med Chem. 2021 Jan
14;64(1):516-526.

2: Sivcev S, Slavikova B, Ivetic M, Knezu M, Kudova E, Zemkova H. Lithocholic
acid inhibits P2X2 and potentiates P2X4 receptor channel gating. J Steroid
Biochem Mol Biol. 2020 Sep;202:105725.

3: Hofmann AF. Detoxification of lithocholic acid, a toxic bile acid: relevance
to drug hepatotoxicity. Drug Metab Rev. 2004 Oct;36(3-4):703-22.

4: Masuno H, Kazui Y, Tanatani A, Fujii S, Kawachi E, Ikura T, Ito N, Yamamoto
K, Kagechika H. Development of novel lithocholic acid derivatives as vitamin D
receptor agonists. Bioorg Med Chem. 2019 Aug 15;27(16):3674-3681.

5: do Nascimento PG, Lemos TL, Almeida MC, de Souza JM, Bizerra AM, Santiago GM,
da Costa JG, Coutinho HD. Lithocholic acid and derivatives: Antibacterial
activity. Steroids. 2015 Dec;104:8-15.

6: Arlia-Ciommo A, Piano A, Svistkova V, Mohtashami S, Titorenko VI. Mechanisms
underlying the anti-aging and anti-tumor effects of lithocholic bile acid. Int J
Mol Sci. 2014 Sep 18;15(9):16522-43.

7: Wong SY, Teo JSM, Chai SF, Yeap SL, Lau AJ. Vitamin E analogues
differentially inhibit human cytochrome P450 3A (CYP3A)-mediated oxidative
metabolism of lithocholic acid: Impact of δ-tocotrienol on lithocholic_acid
cytotoxicity. Toxicology. 2019 Jul 1;423:62-74.

8: Grobe S, Badenhorst CPS, Bayer T, Hamnevik E, Wu S, Grathwol CW, Link A,
Koban S, Brundiek H, Großjohann B, Bornscheuer UT. Engineering Regioselectivity
of a P450 Monooxygenase Enables the Synthesis of Ursodeoxycholic Acid via
7β-Hydroxylation of Lithocholic_Acid. Angew Chem Int Ed Engl. 2021 Jan
11;60(2):753-757.

9: Gaikwad S, González CM, Vilariño D, Lasanta G, Villaverde C, Mouriño A,
Verlinden L, Verstuyf A, Peluso-Iltis C, Rochel N, Berkowska K, Marcinkowska E.
Lithocholic acid-based design of noncalcemic vitamin D receptor agonists. Bioorg
Chem. 2021 Jun;111:104878.
10: Yang B, Zha R, Zhao W, Gong D, Meng X, Zhang Z, Zhu L, Qi N, Wang B.
Comparative transcriptome analysis of the fungus Gibberella zeae transforming
lithocholic acid into ursodeoxycholic acid. Biotechnol Lett. 2021
Feb;43(2):415-422.

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