Iberiotoxin

Product Description

Iberiotoxin
Catalog number: MDP0619
CAS Number: 39465-37-7
Sequence: Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln (Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35)
Amount: 100 ug
Molecular Weight: 4230.8 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Flink MT, Atchison WD. Iberiotoxin-induced block of Ca2+-activated K+ channels induces dihydropyridine sensitivity of ACh release from mammalian motor nerve terminals J Pharmacol Exp Ther. 2003 May;305(2):646-52.
2: Wang Y, Gao T, Shan L, Li K, Liang F, Yu J, Ni Y, Sun P. Iberiotoxin and clofilium regulate hyperactivation, acrosome reaction, and ion homeostasis synergistically during human sperm capacitation Mol Reprod Dev. 2023 Mar;90(3):129-140.
3: Benton MD, Lewis AH, Bant JS, Raman IM. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata J Neurophysiol. 2013 May;109(10):2528-41.
4: Koschak A, Koch RO, Liu J, Kaczorowski GJ, Reinhart PH, Garcia ML, Knaus HG. [125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels Biochemistry. 1997 Feb 18;36(7):1943-52.
5: Candia S, Garcia ML, Latorre R. Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel Biophys J. 1992 Aug;63(2):583-90.
6: Bingham JP, Chun JB, Ruzicka MR, Li QX, Tan ZY, Kaulin YA, Englebretsen DR, Moczydlowski EG. Synthesis of an iberiotoxin derivative by chemical ligation: a method for improved yields of cysteine-rich scorpion toxin peptides Peptides. 2009 Jun;30(6):1049-57.
7: Haghdoost-Yazdi H, Janahmadi M, Behzadi G. Iberiotoxin-sensitive large conductance Ca2+ -dependent K+ (BK) channels regulate the spike configuration in the burst firing of cerebellar Purkinje neurons Brain Res. 2008 May 30;1212:1-8.
8: Schroeder N, Mullmann TJ, Schmalhofer WA, Gao YD, Garcia ML, Giangiacomo KM. Glycine 30 in iberiotoxin is a critical determinant of its specificity for maxi-K versus K(V) channels FEBS Lett. 2002 Sep 11;527(1-3):298-302.
9: Roger S, Potier M, Vandier C, Le Guennec JY, Besson P. Description and role in proliferation of iberiotoxin-sensitive currents in different human mammary epithelial normal and cancerous cells Biochim Biophys Acta. 2004 Dec 15;1667(2):190-9.
10: Giangiacomo KM, Sugg EE, Garcia-Calvo M, Leonard RJ, McManus OB, Kaczorowski GJ, Garcia ML. Synthetic charybdotoxin-iberiotoxin chimeric peptides define toxin binding sites on calcium-activated and voltage-dependent potassium channels Biochemistry. 1993 Mar 9;32(9):2363-70.

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