Folic Acid (Biotechnology Grade)
Catalog Number: B2010164 (1 g)
Folic Acid is a high quality research product used as as substrate for dihydrofolate reductase(s) reactions. Through its convertion into Tetrahydrofolate (THF), Folic Acid is required for de novo synthesis of purines, thymidylic acid and various amino acids as well as for the post-translational methylation od DNA which one of the basis of epigenetics. Custom bulk orders of this product are available upon request.
Catalog number: B2010164
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 1 g
Supplied as: Ready-to-use
Appearance: Yellow/Orange powder
Applications: as substrate for dihydrofolate reductase(s) reactions. Through its convertion into Tetrahydrofolate (THF), Folic Acid is required for de novo synthesis of purines, thymidylic acid and various amino acids as well as for the post-translational methylation od DNA which one of the basis of epigenetics.
Storage: room temperature
Keywords: PteGlu, Pteroyl-L-glutamic acid, Vitamin M, Vitamin B9.
Grade: Biotechnology grade. All components are highly pure (minimum 99%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered on a 0.22 um.
1: Shao D, Li J, Pan Y, Zhang X, Zheng X, Wang Z, Zhang M, Zhang H, Chen L.
Noninvasive theranostic imaging of HSV-TK/GCV suicide gene therapy in liver
cancer by folate-targeted quantum dot-based liposomes. Biomater Sci. 2015
2: Fu L. Use of Smartphone Funduscopy to aid Diagnosis of chorioretinitis after
donor-recipient mismatched cardiac transplantation. BMJ Case Rep. 2017 Sep
3: Shanley JD, Debs RJ. The folate antagonist, methotrexate, is a potent
inhibitor of murine and human cytomegalovirus in vitro. Antiviral Res. 1989
4: Israel DS, Plaisance KI. Neutropenia in patients infected with human
immunodeficiency virus. Clin Pharm. 1991 Apr;10(4):268-79.
5: Walzer PD, Foy J, Steele P, Kim CK, White M, Klein RS, Otter BA, Allegra C.
Activities of antifolate, antiviral, and other drugs in an immunosuppressed rat
model of Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1992
6: Mayer-Kuckuk P, Banerjee D, Malhotra S, Doubrovin M, Iwamoto M, Akhurst T,
Balatoni J, Bornmann W, Finn R, Larson S, Fong Y, Gelovani Tjuvajev J, Blasberg
R, Bertino JR. Cells exposed to antifolates show increased cellular levels of
proteins fused to dihydrofolate reductase: a method to modulate gene expression.
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3400-5.
7: Prichard MN, Prichard LE, Shipman C Jr. Inhibitors of thymidylate synthase
and dihydrofolate reductase potentiate the antiviral effect of acyclovir.
Antiviral Res. 1993 Mar;20(3):249-59.
Products Related to Folic Acid : Biochemical Buffers and Solutions
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